Genetic studies of human apolipoproteins: XII. Population genetics of apolipoproteins in Papua New Guinea
| Autor: | Kuldeep Bhatia, Robert E. Ferrell, M. I. Kamboh |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Apolipoprotein E
Genetics education.field_of_study Apolipoprotein B biology Cholesterol Isoelectric focusing Population Population genetics chemistry.chemical_compound chemistry Anthropology biology.protein lipids (amino acids peptides and proteins) Anatomy Allele education Gene Ecology Evolution Behavior and Systematics |
| Zdroj: | American Journal of Human Biology. 2:17-23 |
| ISSN: | 1520-6300 1042-0533 |
| DOI: | 10.1002/ajhb.1310020103 |
| Popis: | The gene products of the apolipoprotein A-I, A-II, A-IV, C-II, C-III, D, E and H loci have been screened by isoelectric focusing followed by immunoblotting from two Papua New Guinean populations, the Huli and the Pawaia. Only APO E and APO H revealed common polymorphisms. A putative unique A-IV variant has been identified, but due to the lack of family data it is not characterized further. Three common APO H alleles were observed in both groups with comparable frequencies. But significantly different distributions of three APO E alleles were noted in the Huli and the Pawaia. The respective frequencies of the APO E*2, APO E*3, and APO E*4 alleles were 0.154, 0.356, and 0.490 in the Huli and 0.138, 0.603, and 0.259 in the Pawaia. A strikingly high frequency of the APO E*4 allele in Papua New Guinea may provide a useful insight into the studies of genetic and environmental interactions in controlling the cholesterol levels in the general population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text