A Brief Report and Mini-Review of Visceral Leishmaniasis-associated Hemophagocytic Lymphohistiocytosis in Children
| Autor: | Sonia Alexiadou, Elpis Mantadakis, Athanassios Chatzimichael, George Totikidis, Anastasia Grapsa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Antifungal Agents medicine.disease_cause Lymphohistiocytosis Hemophagocytic Serology 03 medical and health sciences 0302 clinical medicine Amphotericin B hemic and lymphatic diseases medicine Humans Child Hemophagocytic lymphohistiocytosis biology business.industry Leishmaniasis Hematology Prognosis medicine.disease biology.organism_classification Epstein–Barr virus Visceral leishmaniasis medicine.anatomical_structure Oncology Immunoglobulin M 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Immunology biology.protein Leishmaniasis Visceral Bone marrow Leishmania infantum business Leishmania donovani 030215 immunology |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 43:e223-e226 |
| ISSN: | 1077-4114 |
| Popis: | We present the case of a 7-year-old boy who fulfilled the diagnostic criteria for hemophagocytic lymphohistiocytosis (HLH). Prompt visualization of his bone marrow confirmed the diagnosis of visceral leishmaniasis (VL). He responded well to treatment with liposomal amphotericin-B. The patient had a false-negative enzyme-linked immunosorbent assay for Leishmania infantum and a false-positive immunoglobulin M test for Epstein Barr virus (EBV). Because age at presentation is similar in children with VL and familial HLH for whom EBV is the usual trigger, ruling out VL is extremely important because nonspecific serologic tests for EBV can lead to the inappropriate diagnosis of EBV-driven primary HLH and to the administration of unnecessary immunochemotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|