Association of serum albumin level with incidence and mortality of overt hepatic encephalopathy in cirrhosis during hospitalization
| Autor: | Zhaohui Bai, Xiaozhong Guo, Hongyu Li, Frank Tacke, Xingshun Qi, Yingying Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Cirrhosis hepatic encephalopathy Gastroenterology 03 medical and health sciences 0302 clinical medicine Serum albumin level Internal medicine medicine Decreased serum albumin lcsh:RC799-869 Hepatic encephalopathy albumin Original Research business.industry cirrhosis Incidence (epidemiology) Albumin Cirrhotic patient medicine.disease mortality 030220 oncology & carcinogenesis incidence lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology Complication business |
| Zdroj: | Therapeutic Advances in Gastroenterology Therapeutic Advances in Gastroenterology, Vol 12 (2019) |
| ISSN: | 1756-2848 |
| DOI: | 10.1177/1756284819881302 |
| Popis: | Background: Hepatic encephalopathy (HE) is a serious complication of cirrhosis. Decreased serum albumin (ALB) level may facilitate the development of HE and accelerate the death of cirrhotic patients with HE. Recent evidence also suggests that human albumin infusion may reduce the incidence of HE and improve the outcomes of cirrhotic patients. This study aimed to explore the association of serum ALB level with the development of overt HE and HE-associated mortality during hospitalization. Methods: Cirrhotic patients admitted to our hospital between January 2010 and February 2019 were screened. Independent predictors for HE were identified by logistic regression analyses. Odds ratio (OR) with 95% confidence interval (95% CI) was calculated. Area under curve (AUC) was calculated by receiver operator characteristic curve analyses. Results: Of the 2376 included patients with cirrhosis but without HE at admission, 113 (4.8%) developed overt HE during hospitalizations. ALB level (OR = 0.878, 95% CI = 0.834–0.924) was an independent risk factor for development of overt HE. AUC of ALB level for predicting the development of overt HE was 0.770 (95% CI = 0.752–0.787, p Conclusions: Decreased serum ALB level may be associated with higher risk of overt HE and HE-associated mortality during hospitalizations in cirrhosis. |
| Databáze: | OpenAIRE |
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