Wound-healing potential of an ethanol extract ofCarica papaya(Caricaceae) seeds
| Autor: | Adash Ramsubhag, Julien R. Marshall, Andrew Adogwa, Ria Ramdeen, Bijoor Shivananda Nayak |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Staphylococcus aureus medicine.medical_specialty Mupirocin Dermatology Biology medicine.disease_cause Caricaceae Rats Sprague-Dawley Hydroxyproline chemistry.chemical_compound Salmonella medicine Animals Wound Healing Ethanol integumentary system Traditional medicine Carica Plant Extracts Granulation tissue Original Articles Antimicrobial biology.organism_classification Rats Surgery medicine.anatomical_structure chemistry Seeds Granulation Tissue Collagen Wound healing |
| Zdroj: | Int Wound J |
| ISSN: | 1742-4801 |
| DOI: | 10.1111/j.1742-481x.2011.00933.x |
| Popis: | Carica papaya L. (Linn) (Caricaceae) is traditionally used to treat various skin disorders, including wounds. It is widely used in developing countries as an effective and readily available treatment for various wounds, particularly burns. This study evaluated the wound-healing and antimicrobial activity of C. papaya seed extract. Ethanol extract of C. papaya seed (50 mg/kg/day) was evaluated for its wound-healing activity in Sprague-Dawley rats using excision wound model. Animals were randomly divided into four groups of six each (group 1 served as control, group 2 treated with papaya seed extract, group 3 treated with a standard drug mupirocin and papaya seed extract (1:1 ratio) and group 4 treated with a mupirocin ointment. Rate of wound contraction and hydroxyproline content were determined to assess the wound-healing activity of the seed extract. The group 2 animals showed a significant decrease in wound area of 89% over 13 days when compared with groups 1 (82%), 3 (86%) and 4 (84%) respectively. The hydroxyproline content was significantly higher with the granulation tissue obtained from group 2 animals which were treated with C. papaya seed extract. Histological analysis of granulation tissue of the group 2 animals showed the deposition of well-organized collagen. The extract exhibited antimicrobial activity against Salmonella choleraesuis and Staphylococcus aureus. Our results suggest that C. papaya promotes significant wound healing in rats and further evaluation for this activity in humans is suggested. |
| Databáze: | OpenAIRE |
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