POLYHYDROXYLATED PYRROLIDINES FROM SUGAR LACTONES - SYNTHESIS OF 1,4-DIDEOXY-1,4-IMINO-D-GLUCITOL FROM D-GALACTONOLACTONE AND SYNTHESES OF 1,4-DIDEOXY-1,4-IMINO-D-ALLITOL, 1,4-DIDEOXY-1,4-IMINO-D-RIBITOL, AND (2S,3R,4S)-3,4-DIHYDROXYPROLINE FROM D-GULONOLACTONE

Autor:	George W. J. Fleet, Jong Chan Son
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	chemistry.chemical_classification biology Stereochemistry Glucosidase Inhibitor Organic Chemistry Ribitol Biochemistry chemistry.chemical_compound Polyol chemistry Enzyme inhibitor Drug Discovery Aldonic acid biology.protein D-glucitol Organic chemistry Glycoside hydrolase Sugar
DOI:	10.1016/s0040-4020(01)81716-6
Popis:	The use of readily available sugar lactones in the synthesis of polyhydroxylated pyrrolidines is illustrated by the preparation of the glucosidase inhibitor 1,4-dideoxy-1, 4-imino-D-glucitol from D-galactonolactone and by the conversion of D-gulonolactone into 1,4-dideoxy-l,4-imino-D-allitol, 1,4-dideoxy-l,4-imino-D-ribitol, and (2S,3R,4S)-3,4-dihydroxyproline.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4761ea4f81d1584ff64257a674d769 https://doi.org/10.1016/s0040-4020(01)81716-6 Zobrazit plný text záznamu