Extremely low birth weight predisposes to impaired renal health : a pooled analysis
| Autor: | Zhenyu Zhang, Anke Raaijmakers, Małgorzata Klimek, Przemko Kwinta, Karel Allegaert, Jan A. Staessen, Andrzej Grudzień, Katarzyna Starzec, Elena Levtchenko, Maja Gilarska |
|---|---|
| Přispěvatelé: | Pediatric Surgery |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system Birth weight 030232 urology & nephrology Renal function Renal complications lcsh:RC870-923 Gastroenterology Prehypertension 03 medical and health sciences 0302 clinical medicine Internal medicine medicine lcsh:Dermatology Cystatin C biology business.industry Extremely low birth weight Gestational age General Medicine lcsh:RL1-803 lcsh:Diseases of the genitourinary system. Urology Low birth weight Blood pressure Nephrology lcsh:RC666-701 Hypertension biology.protein medicine.symptom Cardiology and Cardiovascular Medicine business Cohort study |
| Zdroj: | Kidney & Blood Pressure Research, Vol 44, Iss 5, Pp 897-906 (2019) Kidney & Blood Pressure Research, 44(5), 897-906. Karger |
| ISSN: | 1420-4096 |
| Popis: | Background: A number of studies examined the association between preterm delivery and kidney size and function later in life. However, the number of cases in published cohort studies is low. This study was aimed at performing a multicenter collaboration to pool data to obtain more accurate results to quantify the extent of renal impairment in former extremely low birth weight (ELBW; Methodology: We performed a subject-level meta-analysis to pool data from Cracow (64 cases/34 controls) and Leuven (93 cases/87 controls). We assessed and analyzed cystatin C, estimated glomerular filtration rate (eGFR), ultrasound kidney length, and blood pressure (BP) in 11-year-old ELBW children compared with controls born at term. The prevalence of hypertension (HT) and prehypertension (preHT) in both groups was also analyzed. Results: The study group comprised 157 former ELBW children (gestational age 23–33 weeks and birth weight 430–1,000 g) and 123 children born at term. Former ELBW children had lower mean eGFR (100.62 ± 16.53 vs. 111.89 ± 15.26 mL/min/1.73 m2; p < 0.001), smaller absolute kidney length (8.56 ± 0.78 vs. 9.008 ± 0.73 cm; p = 0.01) and diastolic (68.6 ± 6.8 vs. 66.3 ± 7.7 mm Hg; p = 0.03) BP. Smaller renal size in former ELBW children was positively associated with lower birth weight, shorter gestational age, and severity of perinatal complications (intraventricular hemorrhage, length of stay, mechanical ventilation, and oxygen therapy). Conclusion: ELBW is associated with lower eGFR and a high frequency of preHT and HT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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