Synthesis and SAR of highly selective MMP-13 inhibitors

Autor:	Xuemei Du, Thomas S. Rush, Tam Steve Yik-Kai, Yonghan Hu, Dianne DeVincentis, Jennifer R. Thomason, Kristina Cunningham, Jason Shaoyun Xiang, Jeremy I. Levin, Jianchang Li, Elisabeth A. Morris, Wei Li, Jerauld S. Skotnicki, Priya S. Chockalingam
Rok vydání:	2005
Předmět:	Stereochemistry Clinical Biochemistry Carboxylic Acids Pharmaceutical Science Matrix Metalloproteinase Inhibitors Matrix metalloproteinase Biochemistry Chemical synthesis Inhibitory Concentration 50 Structure-Activity Relationship Matrix Metalloproteinase 13 Drug Discovery Collagenases Enzyme Inhibitors Molecular Biology Amination Benzofurans Aggrecanase chemistry.chemical_classification Molecular Structure biology Organic Chemistry In vitro Sulfonamide Enzyme chemistry Enzyme inhibitor biology.protein Molecular Medicine Selectivity Sulfur
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 15:4961-4966
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2005.08.001
Popis:	The structure-based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP-13 inhibitors with selectivity over MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14, Aggrecanase 1, and TACE are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b44ddefc7ea6586738dcff00b25091c https://doi.org/10.1016/j.bmcl.2005.08.001 Zobrazit plný text záznamu Full Text from ScienceDirect