Cholesteryl ester transfer protein (CETP) increases postprandial triglyceridaemia and delays triacylglycerol plasma clearance in transgenic mice
| Autor: | Alessandro G. Salerno, P.R. Patricio, Helena C. F. Oliveira, J.A. Berti |
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| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
Very low-density lipoprotein medicine.medical_specialty Cholesterol VLDL Hyperlipidemias Mice Transgenic Biochemistry Mice chemistry.chemical_compound High-density lipoprotein Internal medicine Chylomicrons Cholesterylester transfer protein medicine Animals Molecular Biology LDL-Receptor Related Proteins Triglycerides Intermediate-density lipoprotein Lipoprotein lipase biology Fasting Organ Size Cell Biology Postprandial Period Dietary Fats Cholesterol Ester Transfer Proteins carbohydrates (lipids) Lipoprotein Lipase Endocrinology Intestinal Absorption Liver chemistry biology.protein Cholesteryl ester Emulsions Female lipids (amino acids peptides and proteins) Hepatic lipase Lipoprotein |
| Zdroj: | Biochemical Journal. 419:629-634 |
| ISSN: | 1470-8728 0264-6021 |
| Popis: | The CETP (cholesteryl ester transfer protein) is a plasma protein synthesized in several tissues, mainly in the liver; CETP reduces plasma HDL (high-density lipoprotein) cholesterol and increases the risk of atherosclerosis. The effect of CETP levels on postprandial intravascular metabolism of TAGs (triacylglycerols) is an often-overlooked aspect of the relationship between CETP and lipoprotein metabolism. Here, we tested the hypothesis that CETP delays the plasma clearance of TAG-rich lipoprotein by comparing human CETP expressing Tg (transgenic) and non-Tg mice. After an oral fat load, the postprandial triglyceridaemia curve was markedly increased in CETP-Tg compared with non-Tg mice (280±30 versus 190±20 mg/dl per 6 h respectively, P |
| Databáze: | OpenAIRE |
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