Full-genome sequence analysis of an uncommon norovirus genotype, GII.21, from South Korea
| Autor: | Jun Won Yun, H. G. Cho, Chul Jong Park, Junguee Lee, Sung-Geun Lee, S Y Paik, Y J Park |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Genotype Epidemiology Sequence analysis viruses Genome Viral Biology medicine.disease_cause Genome Viral Proteins 03 medical and health sciences Republic of Korea Prevalence medicine Amino Acid Sequence Peptide sequence Phylogeny Caliciviridae Infections Sequence (medicine) Genetics Phylogenetic tree Strain (biology) Norovirus virus diseases Original Papers Gastroenteritis 030104 developmental biology Infectious Diseases Sequence Alignment |
| Zdroj: | Epidemiol Infect |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268817001273 |
| Popis: | SUMMARYNoroviruses (NoVs) are major causal agents of acute gastroenteritis in humans. NoV GII.4 is the predominant genotype globally. However, uncommon and minor types of NoVs are consistently detected and some have been shown to dominate over GII.4. Therefore, the prevalence of dominant and uncommon NoVs makes the identification of these viruses important for the prediction and prevention of pandemics. In this study, the full-genome sequence of a NoV (strain JW) detected in Korea was extensively characterized. The full-length genome was 7510 nucleotides long, and phylogenetic analysis based on the whole-genome sequences, including open reading frame (ORF)1, ORF2, and ORF3, indicated that it belonged to the GII.21 genotype. Strain JW showed maximum identity with strain YO284; however, comparison of the amino acid sequence of ORF2, which functions as an antigen, showed substitutions in several amino acids. GII.21 is not a prevalent epidemiological agent of acute gastroenteritis in humans, but it is consistently found in gastroenteritis patients from several countries. The present study provides the first full-genome sequence analysis of NoV GII.21 isolated from a patient in Korea. Our findings provide not only valuable genome information but also data for epidemiology studies, epidemic prevention, and vaccine development strategies. |
| Databáze: | OpenAIRE |
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