A Mediterranean-like dietary pattern with vitamin D3 (10 µg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trial

Autor: Agnes A M Berendsen, Elodie Caumon, Aedin Cassidy, Barbara Pietruszka, Corinne Malpuech-Brugère, Nathalie Meunier, Rita Ostan, Claudio Franceschi, Kirsten G. Dowling, Elzbieta Wierzbicka, Giuseppe Battista, Rachel Gillings, Susan J. Fairweather-Tait, Alberto Bazzocchi, Aurelia Santoro, Amy Jennings, William D. Fraser, George L J Hull, Lisette C. P. G. M. de Groot, Jonathan Tang, Kevin D. Cashman
Přispěvatelé: Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Cork Centre for Vitamin D and Nutrition Research, University College Cork (UCC), College of Medicine and Health, Division of Human Nutrition and Health, Wageningen University and Research [Wageningen] (WUR), Department human Nutrition, Warsaw University of Life Sciences (SGGW), Centro Interdipartimentale « L. Galvani» (CIG), Università di Bologna, Istituto Ortopedico Rizzoli di Bologna, Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre de Recherche en Nutrition Humaine, Institute of Neurological Science of Bologna (IRCCS), European Union's Seventh Framework Program 266486, European Project: 266486,EC:FP7:KBBE,FP7-KBBE-2010-4,NU-AGE(2011), Jennings A, Cashman KD, Gillings R, Cassidy A, Tang J, Fraser W, Dowling KG, Hull GLJ, Berendsen AAM, de Groot LCPGM, Pietruszka B, Wierzbicka E, Ostan R, Bazzocchi A, Battista G, Caumon E, Meunier N, Malpuech-Brugère C, Franceschi C, Santoro A, Fairweather-Tait SJ, Wageningen University and Research Center (WUR), Centre Hospitalier Universitaire de Clermont-Ferrand, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), University of East Anglia [Norwich] (UEA), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Bone density
Osteoporosis
Medicine (miscellaneous)
vitamin D
Diet
Mediterranean
bone
law.invention
older adult
chemistry.chemical_compound
0302 clinical medicine
Randomized controlled trial
law
Bone Density
Medicine
Amino Acids
Vitamin D
older adults
Cholecalciferol
Human Nutrition & Health
2. Zero hunger
Bone mineral
Whole Grains
Nutrition and Dietetics
Femur Neck
Humane Voeding & Gezondheid
3. Good health
Europe
Original Research Communications
medicine.anatomical_structure
Parathyroid Hormone
Female
Collagen
Vitamin
medicine.medical_specialty
030209 endocrinology & metabolism
elderly
Bone and Bones
03 medical and health sciences
dietary intervention
Internal medicine
Mediterranean diet
Vitamin D and neurology
Humans
Olive Oil
Femoral neck
Aged
VLAG
Global Nutrition
Wereldvoeding
Vitamin D supplementation
030109 nutrition & dietetics
business.industry
Osteoporosi
medicine.disease
Osteopenia
chemistry
Dietary Supplements
bone mineral density
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Biomarkers
Zdroj: American Journal of Clinical Nutrition
American Journal of Clinical Nutrition, American Society for Nutrition, 2018, 108 (3), pp.633-640. ⟨10.1093/ajcn/nqy122⟩
The American Journal of Clinical Nutrition
The American Journal of Clinical Nutrition, 2018, 108 (3), pp.633-640. ⟨10.1093/ajcn/nqy122⟩
American Journal of Clinical Nutrition 108 (2018) 3
Jennings, A, Cashman, K D, Gillings, R, Cassidy, A, Tang, J, Fraser, W, Dowling, K G, Hull, G LJ, Berendsen, A AM, de Groot, L CPGM, Pietruszka, B, Wierzbicka, E, Ostan, R, Bazzocchi, A, Battista, G, Caumon, E, Meunier, N, Malpuech-Brugère, C, Franceschi, C, Santoro, A & Fairweather-Tait, S J 2018, ' A Mediterranean-like dietary pattern with vitamin D3 (10 µg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trial ', American Journal of Clinical Nutrition, vol. 108, no. 3, pp. 633–640 . https://doi.org/10.1093/ajcn/nqy122
American Journal of Clinical Nutrition, 108(3), 633-640
ISSN: 0002-9165
1938-3207
DOI: 10.1093/ajcn/nqy122⟩
Popis: Background: The Mediterranean diet (MD) is widely recommended for the prevention of chronic disease, but evidence for a beneficial effect on bone health is lacking. Objective: The aim of this study was to examine the effect of a Mediterranean-like dietary pattern [NU-AGE (New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe)] on indexes of inflammation with a number of secondary endpoints, including bone mineral density (BMD) and biomarkers of bone and collagen degradation in a 1-y multicenter randomized controlled trial (RCT; NU-AGE) in elderly Europeans. Design: An RCT was undertaken across 5 European centers. Subjects in the intervention group consumed the NU-AGE diet for 1 y by receiving individually tailored dietary advice, coupled with supplies of foods including whole-grain pasta, olive oil, and a vitamin D3 supplement (10 µg/d). Participants in the control group were provided with leaflets on healthy eating available in their country. Results: A total of 1294 participants (mean ± SD age: 70.9 ±4.0 y; 44% male) were recruited to the study and 1142 completed the 1-y trial. The Mediterranean-like dietary pattern had no effect on BMD (site-specific or whole-body); the inclusion of compliance to the intervention in the statistical model did not change the findings. There was also no effect of the intervention on the urinary biomarkers free pyridinoline or free deoxypyridinoline. Serum 25-hydroxyvitamin D significantly increased and parathyroid hormone decreased (P < 0.001) in the MD compared with the control group. Subgroup analysis of individuals with osteoporosis at baseline (site-specific BMD T-score ≤ −2.5 SDs) showed that the MD attenuated the expected decline in femoral neck BMD (n = 24 and 30 in MD and control groups, respectively; P = 0.04) but had no effect on lumbar spine or whole-body BMD. Conclusions: A 1-y intervention of the Mediterranean-like diet together with vitamin D3 supplements (10 µg/d) had no effect on BMD in the normal age-related range, but it significantly reduced the rate of loss of bone at the femoral neck in individuals with osteoporosis. The NU-AGE trial is registered at clinicaltrials.gov as NCT01754012.
Databáze: OpenAIRE
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