Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI

Autor: Hedieh Honarpisheh, Kristina Biado, Anna E. Blanken, Denise W. Ng, Liana G. Apostolova, Jenny Brook, Harry V. Vinters, Emily Kraft, Chris Zarow, Johanne Somme, Darrick Lo, Sona Hurtz, Spencer Tung
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Brain atrophy
Pathology
Hippocampal formation
Hippocampus
lcsh:RC346-429
Imaging
Cohort Studies
chemistry.chemical_compound
0302 clinical medicine
Neuropathology
Aged
80 and over
biology
Subiculum
Regular Article
Middle Aged
Alzheimer's disease
Magnetic Resonance Imaging
Temporal Lobe
Neurology
lcsh:R858-859.7
Female
Psychology
MRI
Adult
medicine.medical_specialty
Amyloid beta
Cognitive Neuroscience
lcsh:Computer applications to medicine. Medical informatics
Young Adult
03 medical and health sciences
Cresyl violet
Atrophy
Alzheimer Disease
medicine
Humans
Dementia
Radiology
Nuclear Medicine and imaging
lcsh:Neurology. Diseases of the nervous system
Aged
medicine.disease
030104 developmental biology
nervous system
chemistry
biology.protein
Neurology (clinical)
Neuroscience
030217 neurology & neurosurgery
Zdroj: NeuroImage : Clinical
NeuroImage: Clinical, Vol 15, Iss, Pp 56-61 (2017)
ISSN: 2213-1582
Popis: Hippocampal atrophy, amyloid plaques, and neurofibrillary tangles are established pathologic markers of Alzheimer's disease. We analyzed the temporal lobes of 9 Alzheimer's dementia (AD) and 7 cognitively normal (NC) subjects. Brains were scanned post-mortem at 7 Tesla. We extracted hippocampal volumes and radial distances using automated segmentation techniques. Hippocampal slices were stained for amyloid beta (Aβ), tau, and cresyl violet to evaluate neuronal counts. The hippocampal subfields, CA1, CA2, CA3, CA4, and subiculum were manually traced so that the neuronal counts, Aβ, and tau burden could be obtained for each region. We used linear regression to detect associations between hippocampal atrophy in 3D, clinical diagnosis and total as well as subfield pathology burden measures. As expected, we found significant correlations between hippocampal radial distance and mean neuronal count, as well as diagnosis. There were subfield specific associations between hippocampal radial distance and tau in CA2, and cresyl violet neuronal counts in CA1 and subiculum. These results provide further validation for the European Alzheimer's Disease Consortium Alzheimer's Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP).
Highlights • We researched the correlations of hippocampal radial distance with Alzheimer's pathology. • Hippocampal radial distance was associated with mean neuronal count and diagnosis. • Our findings support for the use of hippocampal surface mapping in AD research.
Databáze: OpenAIRE
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