Evaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil
| Autor: | Shanshan Xiao, Weirong Yao, Jiajia Fan, Hang Yu, Yunfei Xie, Yahui Guo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
eye irritation
Analgesic Cinnamomum camphora Bioengineering acute toxicity Applied Microbiology and Biotechnology law.invention Borneol Steam distillation chemistry.chemical_compound pain-related factor skin irritation law medicine Prostaglandin E2 Essential oil biology Traditional medicine Chemistry analgesia General Medicine biology.organism_classification Acute toxicity Draize test TP248.13-248.65 medicine.drug Biotechnology |
| Zdroj: | Bioengineered, Vol 12, Iss 2, Pp 9860-9871 (2021) |
| ISSN: | 2165-5987 2165-5979 |
| Popis: | Cinnamomum camphora chvar. Borneol essential oil (BEO, 18.2% v/v borneol) is a by-product of steam distillation to produce natural crystalline borneol (NCB, 98.4% v/v borneol). Given the known medicinal properties of borneol, the analgesic function and safety were studied. Horn's method and the Draize test revealed a gender difference in mice regarding acute oral LD50, i.e., low-toxicity to female mice (2749 mg/kg), but practically non-toxic to male mice (5081 mg/kg). There was no acute and skin or eye irritation when BEO was applied directly, if the BEO concentration was less than 50%. The analgesic effect of BEO was evaluated by the glacial acetic acid-induced writhing pain model. Continuous topical application of BEO to the abdomen of mice for 6 d, significantly reduced observed writhing in mice (p < 0.001) with a strong dose-response relationship (r = -0.9006). Concomitantly, the levels of the serum pain-related mediators, prostaglandin E2 (PGE2) and transient receptor potential melastatin-8 (TRPM8) were significantly reduced (p < 0.001), and the latter showed a strong dose-response relationship (r = -0.9427). Therefore, BEO had similar analgesic functions to borneol and was demonstrated to be safe for medicinal use. |
| Databáze: | OpenAIRE |
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