Free Thyroxine Concentrations in Sera of Individuals with Familial Dysalbuminemic Hyperthyroxinemia: A Comparison of Three Methods of Measurement
| Autor: | Michael J. McPhaul, Samuel Refetoff, Zengru Wu, Neal H. Scherberg, Chao Yuan, William W. Wu |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Thyroid Hormones medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Thyroid Function Tests Gene mutation Original Studies Elevated serum 03 medical and health sciences 0302 clinical medicine Endocrinology Reference Values Tandem Mass Spectrometry Albumins Internal medicine medicine Humans Euthyroid Child Dialysis Aged Clinical Laboratory Techniques business.industry Free thyroxine index Hyperthyroxinemia Familial Dysalbuminemic Albumin Infant Free thyroxine Middle Aged medicine.disease Thyroxine Familial dysalbuminemic hyperthyroxinemia Child Preschool 030220 oncology & carcinogenesis Mutation Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Thyroid |
| ISSN: | 1557-9077 1050-7256 |
| Popis: | Background: Euthyroid individuals with familial dysalbuminemic hyperthyroxinemia (FDH) have often falsely elevated serum free thyroxine (fT4) concentrations determined by different automated immunoassays. Methods: We measured serum fT4 using direct dialysis coupled with tandem mass spectrometry (fT4 DDMS) in individuals with the common albumin gene mutation (ALB R218H) from 14 FDH families and compared them with results obtained by direct immunometric assay (fT4 DIMM) and free thyroxine index (fT4I). Results: While all 14 individuals with FDH had elevated total serum T4, the fT4 measured by DIMM was elevated in 12, by fT4I in 5, and by DDMS in 1. Conclusion: The latter method greatly reduced the discordance of fT4 results relative to thyrotropin in FDH. |
| Databáze: | OpenAIRE |
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