Field programmable gate array compression for large array multispeckle diffuse correlation spectroscopy
| Autor: | Francescopaolo Mattioli Della Rocca, Edbert J. Sie, Ryan Catoen, Francesco Marsili, Robert K. Henderson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Biomaterials
Photons diffuse correlation spectroscopy field-programmable gate array compression Spectrum Analysis Biomedical Engineering multispeckle single-photon avalanche diode Signal-To-Noise Ratio Data Compression Atomic and Molecular Physics and Optics Algorithms Electronic Optical and Magnetic Materials |
| Zdroj: | Mattioli Della Rocca, F, Sie, E, Catoen, R, Marsili, F & Henderson, R K 2023, ' Field programmable gate array compression for large array multispeckle diffuse correlation spectroscopy ', Journal of Biomedical Optics, vol. 28, no. 5, 057001 . https://doi.org/10.1117/1.JBO.28.5.057001 |
| DOI: | 10.1117/1.JBO.28.5.057001 |
| Popis: | Significance: Diffuse correlation spectroscopy (DCS) is an indispensable tool for quantifying cerebral blood flow noninvasively by measuring the autocorrelation function (ACF) of the diffused light. Recently, a multispeckle DCS approach was proposed to scale up the sensitivity with the number of independent speckle measurements, leveraging the rapid development of single-photon avalanche diode (SPAD) cameras. However, the extremely high data rate from advanced SPAD cameras is beyond the data transfer rate commonly available and requires specialized high-performance computation to calculate large number of autocorrelators (ACs) for real-time measurements. Aim: We aim to demonstrate a data compression scheme in the readout field-programmable gate array (FPGA) of a large-pixel-count SPAD camera. On-FPGA, data compression should democratize SPAD cameras and streamline system integration for multispeckle DCS. Approach: We present a formula presented SPAD array with 128 linear ACs embedded on an FPGA to calculate 12,288 ACFs in real time. Results: We achieved a signal-to-noise ratio (SNR) gain of 110 over a single-pixel DCS system and more than threefold increase in SNR with respect to the state-of-the-art multispeckle DCS. Conclusions: The FPGA-embedded autocorrelation algorithm offers a scalable data compression method to large SPAD array, which can improve the sensitivity and usability of multispeckle DCS instruments. |
| Databáze: | OpenAIRE |
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