The clinical significance of regional variations in histologic differentiation within carcinomas of the colorectum
| Autor: | Toshiaki Yoshioka, Kenji Koyama, Yutaka Shibata, Takemi Fukuoka, Osamu Aizawa, Hitoshi Kotanagi |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Pathology medicine.medical_specialty Colorectal cancer Rectum Adenocarcinoma Neoplasms Multiple Primary Surgical oncology medicine Carcinoma Humans Clinical significance Neoplasm Staging Epithelioma business.industry Incidence (epidemiology) Cancer General Medicine Middle Aged medicine.disease Adenocarcinoma Mucinous Survival Rate medicine.anatomical_structure Lymphatic Metastasis Female Surgery Colorectal Neoplasms business |
| Zdroj: | Surgery Today. 23:407-411 |
| ISSN: | 1436-2813 0941-1291 |
| DOI: | 10.1007/bf00309498 |
| Popis: | The clinical significance of the presence or absence of regional variations in histologic differentiation within a primary colorectal carcinoma was investigated in this study. Regional variations in histologic differentiation were judged to be present when the low power field of a microscope was occupied by cancer tissue cytologically and architecturally different from that of the surrounding area. Regional variations in histologic differentiation were noted in 153 (42%) of 368 primary carcinomas. Carcinomas with regional variations were of an anaplastic histologic type and had a higher incidence of lymph node metastasis and a worse prognosis than those without regional variations. Thus, the histologic diversity within a carcinoma is thought to be important for determining the prognosis of patients with colorectal cancer. |
| Databáze: | OpenAIRE |
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