| Popis: |
1) We aimed to conduct a review of the literature for gene polymorphisms associated with susceptibility to gingivitis. We searched the studies in English language using the key words gingivitis and gene (mutation or polymorphism) and analyzed their results. (a) Firstly, in introduction, etiopathogenesis and clinical picture of gingivitis were discussed, the role of genetics in this disease was analyzed and different approaches for genetic studies described. (b) Secondly, candidate genes in relation to gingivitis were analyzed and discussed in relation to various carriage rates of the rare (R)-allele, different environmental and other risk factors. 2) In addition, new data (still unpublished) about the role of interleukin-18 (IL-18) gene polymorphisms at positions -607C/A (rs1946518), -137G/C (rs187238) and -133C/G (rs360721) in relation to gingivitis and microbial pathogens in Czech children are presented in this chapter. |
