Intermediate Stage Complex Regional Pain Syndrome Type 1 Is Unrelated to Proinflammatory Cytokines
| Autor: | Frank J P M Huygen, Freek J. Zijlstra, Martine Boersma, Claudia Heijmans-Antonissen, Christel Muis, Renate J. M. Munnikes |
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| Přispěvatelé: | Anesthesiology |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Visual analogue scale education Immunology Inflammation Disease behavioral disciplines and activities Gastroenterology Proinflammatory cytokine Research Communication Internal medicine medicine lcsh:Pathology Humans Interleukin 6 Pain Measurement biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Interleukin Cell Biology Middle Aged medicine.disease Complex regional pain syndrome McGill Pain Questionnaire biology.protein Female medicine.symptom Inflammation Mediators business Complex Regional Pain Syndromes lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation, 6, 366-372. Hindawi Publishing Corporation Mediators of Inflammation Mediators of Inflammation, Vol 2005, Iss 6, Pp 366-372 (2005) |
| ISSN: | 0962-9351 |
| DOI: | 10.1155/MI.2005.366 |
| Popis: | The aim of this paper is to determine the involvement of tumour necrosis factor-α(TNF-α) and interleukin (IL)-6 in intermediate CRPS 1 as locally formed mediators of inflammation. In this study, 25 patients with proven CRPS 1 (Bruehl criteria) were included. All patients participated in one of our earlier studies during the acute stage of their disease. After the disease developed into an intermediate stage, both the disease activity and the profile of inflammatory mediators were reevaluated. Disease activity and impairment were determined by means of a visual analogue scale, the McGill Pain Questionnaire, the difference in volume and temperature between the involved and uninvolved extremities, and the reduction in active range of motion of the involved extremity. Suction blisters were made on the involved and uninvolved extremities for measurement of IL-6 and TNF-α. A significant improvement in signs and symptoms of impairment was found. However, the levels of IL-6 and TNF-αin blister fluid in the involved extremity versus uninvolved extremity were still significantly raised. Although signs and symptoms are significantly improved, proinflammatory cytokines are still increased in CRPS 1 affected extremities during the intermediate stage of the disease. This indicates that the initiation and sustained development of the disease are only partially affected by proinflammatory cytokines. Follow-up in the chronic stage is necessary to draw more definite conclusions about the existence of a supposed relation between clinical signs and symptoms and the level of proinflammatory cytokines. |
| Databáze: | OpenAIRE |
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