Mapping connectivity fingerprints for presurgical evaluation of temporal lobe epilepsy
| Autor: | Gerard Plans, Júlia Miró, Mercè Falip, Antoni Rodríguez-Fornells, Estela Camara, Mila Santurino, J. Sala-Padró, Xavier Rifà-Ros |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Neurology Lòbul temporal Logistic regression Temporal lobe Epilepsy Seizures Humans Medicine Neurochemistry RC346-429 Cervell Resting state fMRI business.industry Research Brain Biomarker General Medicine Prognosis medicine.disease Magnetic Resonance Imaging Temporal Lobe nervous system diseases Epilèpsia nervous system Epilepsy Temporal Lobe Biomarker (medicine) Surgery Neurology. Diseases of the nervous system Neurology (clinical) Radiology Neurosurgery business psychological phenomena and processes |
| Zdroj: | BMC Neurology BMC Neurology, Vol 21, Iss 1, Pp 1-11 (2021) Dipòsit Digital de la UB Universidad de Barcelona |
| ISSN: | 1471-2377 |
| DOI: | 10.1186/s12883-021-02469-1 |
| Popis: | Background Surgery may render temporal lobe epilepsy (TLE) patients seizure-free. However, TLE is a heterogenous entity and surgical prognosis varies between patients. Network-based biomarkers have been shown to be altered in TLE patients and hold promise for classifying TLE subtypes and improving pre-surgical prognosis. The aim of the present study is to investigate a network-based biomarker, the weighted degree of connectivity (wDC), on an individual level, and its relation to TLE subtypes and surgical prognosis. Methods Thirty unilateral TLE patients undergoing the same surgical procedure (anterior temporal resection) and 18 healthy controls were included. All patients were followed-up in the same center for a mean time of 6.85 years and classified as seizure-free (SF) and non seizure-free (non-SF). Using pre-surgical resting state functional MRI, whole brain wDC values for patients and controls were calculated. Then, we divided both temporal lobes in three Regions-of-interest (ROIs) -mesial, pole and lateral- as these areas are known to behave differently in seizure onset and propagation, delimiting different TLE profiles. The wDC values for the defined ROIs of each individual patient were compared with the healthy group. Results After surgery, 14 TLE patients remained SF. As a group, patients had higher wDC than controls in both the temporal pole (p p p p Conclusions This study provides a network-based presurgical biomarker that could pave the way towards personalized prediction. In patients with TLE undergoing anterior temporal resections, having an increased wDC at rest could be a signature of the epileptogenic area, and could help identifying those patients who would benefit most from surgery. |
| Databáze: | OpenAIRE |
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