COMET – effectiveness and tolerability of methocarbamol versus oral opioid-analgesics as add-on measure in patients with non-specific low back pain refractory to recommended 1st line treatments. A retrospective analysis of depersonalized propensity score matched open-label real-world 4-week data from the German Pain e-Registry
| Autor: | Michael A Ueberall, Gerhard Hh Mueller-Schwefe |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Internal medicine medicine Humans Registries Propensity Score Adverse effect Retrospective Studies Analgesics Methocarbamol business.industry Incidence (epidemiology) General Medicine Low back pain Discontinuation Analgesics Opioid Treatment Outcome Tolerability Propensity score matching Morphine medicine.symptom business Low Back Pain medicine.drug |
| Zdroj: | Current Medical Research and Opinion. 38:237-253 |
| ISSN: | 1473-4877 0300-7995 |
| DOI: | 10.1080/03007995.2021.2003105 |
| Popis: | BACKGROUND To compare the 4-week effectiveness and tolerability of an add-on treatment with oral high dose methocarbamol (MET) vs long-acting oral opioid analgesics (LAO) in patients with non-specific low back pain (nsLBP) poorly responsive to recommended 1st line treatments. METHODS Analysis of anonymized, propensity score-matched real-world data from the German Pain e-Registry, using a sequential non-inferiority superiority approach, for adult outpatients with nsLBP who had initiated treatment with MET or LAO between January 1st, 2018, and December 31st, 2019 (EUPAS identifier: 38484). The primary effectiveness variable was the absolute change of the average 24-hr. pain intensity index (PIX). Safety was assessed by incidence of physician-confirmed drug-related adverse events (DRAEs), and DRAEs leading to discontinuation. RESULTS Propensity score-matched data were analyzed for 374 patients treated with MET and 374 patients treated with LAO. Mean ± SD (median) MET dose over the 4-week evaluation period was 2390.4 ± 1980 (3000) mg and 69.6 ± 25.9 (60) mg morphine equivalent for LAO. With 25.8 ± 11.4 (median 26, 95%-CI: 24.5-27.1) vs. 11.4 ± 6.8 (median 11; 95%-CI: 10.6-12.2) mm VAS, absolute 4-week improvement vs. baseline was superior for MET vs. LAO [p |
| Databáze: | OpenAIRE |
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