Insulin resistance and coronary risk factors in Japanese type 2 diabetic patients with definite coronary artery disease
| Autor: | Seibei Miyake, Yukitaka Ueki, Tan Tominaga, Satoki Fukae, Masako Tomihira, Yoshihisa Kizaki, Kazunari Matsumoto, Yasunori Sera |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Myocardial Infarction Blood Pressure Coronary Disease Type 2 diabetes White People Coronary artery disease Endocrinology Insulin resistance Asian People Japan Risk Factors Diabetes mellitus Internal medicine Internal Medicine medicine Humans Risk factor Triglycerides Aged Glycated Hemoglobin C-Peptide business.industry Insulin Cholesterol HDL Smoking Insulin tolerance test Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease Cholesterol Diabetes Mellitus Type 2 Female Insulin Resistance business Diabetic Angiopathies Lipoprotein(a) |
| Zdroj: | Diabetes Research and Clinical Practice. 51:181-186 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/s0168-8227(00)00228-x |
| Popis: | Insulin resistance is known as an important risk factor for coronary artery disease (CAD). However, CAD-related mortality in Japanese type 2 diabetics is lower than in Caucasians. To investigate whether insulin resistance is related to CAD in Japanese type 2 diabetics, we measured insulin sensitivity and several coronary risk factors in Japanese patients with type 2 diabetes with and without CAD. Thirty-three patients with definite CAD and 33 age- and sex-matched patients without CAD (control) were studied. Insulin sensitivity was assessed by the K index of insulin tolerance test (KITT). Clinical characteristics, classical risk factors, lipoprotein (a), and insulin sensitivity were compared between the two groups. Patients with CAD had a significantly longer duration of diabetes (9.0 +/- 1.4 vs. 5.5 +/- 0.9 years, P0.05, respectively), were mostly hypertensive (69.7 vs. 39.4%, P0.05), and more likely to be treated with insulin (45.5 vs. 18.2%, P0.05) compared with the control. Concerning the metabolic parameters, patients with CAD had a significantly higher insulin resistance than control (2.40 +/- 0.15 vs. 3.23 +/- 0.17%/min, P0.01, respectively), higher triglyceride (1.39 +/- 0.10 vs. 1.05 +/- 0.05 mmol/l, P0.05), lower HDL cholesterol (1.05 +/- 0.05 vs. 1.28 +/- 0.06 mmol/l, P0.05), and higher lipoprotein (a) (27.5 +/- 4.3 vs. 17.4 +/- 2.0 mg/dl, P0.05). Multiple logistic regression analysis indicated that hypertension, insulin resistance, high lipoprotein (a) and triglyceride, and low HDL cholesterol were independently related to CAD. Our results suggest that insulin resistance per se is a significant risk factor for CAD in Japanese patients with type 2 diabetes. |
| Databáze: | OpenAIRE |
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