Are nociceptin(1-13)NH2and its structural analogue [ORN9]nociceptin(1-13)NH2able to affect brain antioxidant status in control and kainic acid-treated rats?
| Autor: | Albena Alexandrova, Lubomir Petrov, Galina Nenkova, Margarita Kirkova, Almira Pavlova, Elina Tzvetanova, Radoslav Girchev, Emilia Naydenova |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Kainic acid medicine.medical_specialty Antioxidant medicine.medical_treatment Clinical Biochemistry Glutathione reductase Biochemistry Antioxidants Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar chemistry.chemical_classification Kainic Acid biology Glutathione peroxidase Brain Cell Biology General Medicine Glutathione Peptide Fragments Rats nervous system diseases Nociceptin receptor Endocrinology Opioid Peptides nervous system chemistry Case-Control Studies biology.protein Lipid Peroxidation |
| Zdroj: | Cell Biochemistry and Function. 27:243-250 |
| ISSN: | 1099-0844 0263-6484 |
| DOI: | 10.1002/cbf.1566 |
| Popis: | In-vivo effects of nociceptin (N/OFQ(1-13)NH2) on the levels of lipid peroxidation and cell enzyme (superoxide dismutase, glutathione peroxidase and glutathione reductase) and non-enzyme (glutathione) antioxidants in brain of control and kainic acid-treated rats were studied. N/OFQ(1-13)NH2 effects were compared with those of its structural analogue [Orn9]N/OFQ(1-13)NH2. Kainic acid (25 µg, i.c.v) increased the lipid peroxidation (4 and 24 h after kainic acid treatment) and decreased the glutathione level (1 h after kainic acid injection). We failed to find, any changes in antioxidant enzyme activities, independently of the time of kainic acid treatment. At the background of kainic acid-effects, N/OFQ(1-13)NH2 and [Orn9] N/OFQ(1-13)NH2, injected 30 min before kainic acid, had no effects on all parameters, tested in brain. In addition, the neuropeptides did not change the antioxidant status in brain of control animals. It might be concluded that N/OFQ(1-13)NH2 and [Orn9]N/OFQ(1-13)NH2 have neither pro- nor anti-oxidant activity. Copyright © 2009 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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