Morphine Addiction Causes Pronounced Virus Replication in Cerebral Compartment and Accelerated Onset of AIDS in SIV/SHIV-infected Indian Rhesus Macaques
| Autor: | Silvija I. Staprans, Anil Kumar, Yasuhiro Yamamura, Grissell Tirado, Nayra Rodríguez, Rakesh Kumar |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
biology Disease progression medicine.disease Blood–brain barrier Virology Infectious Diseases medicine.anatomical_structure Immune system Acquired immunodeficiency syndrome (AIDS) Viral replication Immunology medicine biology.protein Antibody lcsh:RC581-607 Morphine Addiction Viral load |
| Zdroj: | Retrovirology, Vol 2, Iss Suppl 1, p S152 (2005) |
| ISSN: | 1742-4690 |
| DOI: | 10.1186/1742-4690-2-s1-s152 |
| Popis: | Six morphine-dependent and 3 control male Indian rhesus macaques were intravenously inoculated with mixture of SHIVKU, SHIV89.6P and SIV/17E-Fr. These animals were followed for a period of 56 weeks for virus replication, disease progression and immune responses. Both morphinedependent and control macaques showed precipitous loss of CD4+ T cells but CD4 recovery was found to better in more control animals than that in the morphine-dependent animals. The plasma and CSF viral load was significantly higher in morphine-dependent group than those in the control group. Four morphine-dependent succumbed to SIV/SHIV-induced AIDS at week 18, 19, 20 and 51, post-infection with neurological disorders in 3 of those 4 animals. Other 2 morphine-dependent and 3 controls were still alive at the end of 56 week observation period. All 3 viruses replicated in the blood of both morphinedependent and control macaques, but cerebral compartment showed a selection phenomenon and only SIV/17EFr and SHIVKU crossed the blood brain barrier (BBB). The morphine-dependent macaques further favored the viral migration through blood brain barrier (BBB). Three morphine-dependent macaques (euthanized at weeks 18, 19 and 20) did not develop cellular or humoral immune responses whereas other 3 morphine-dependent and 3 control macaques developed both cellular and humoral immune responses. from 2005 International Meeting of The Institute of Human Virology Baltimore, USA, 29 August – 2 September 2005 |
| Databáze: | OpenAIRE |
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