The feasibility of 18F-fluorodeoxyglucose-positron emission tomography uptake as a prognostic factor for paranasal sinus malignancy
| Autor: | Jeong Hun Seol, Jong Doo Lee, Joo-Heon Yoon, Jeung Gweon Lee, Chang Hoon Kim, Jinna Kim |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Nose Neoplasms Standardized uptake value FDG-Positron Emission Tomography Malignancy Nose neoplasm Fluorodeoxyglucose F18 Paranasal Sinuses medicine Immunology and Allergy Humans Grading (tumors) Survival analysis Aged Neoplasm Staging Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Head and neck cancer General Medicine Middle Aged medicine.disease Prognosis Survival Analysis Otorhinolaryngology Positron emission tomography Positron-Emission Tomography Carcinoma Squamous Cell Disease Progression Feasibility Studies Female Radiology Radiopharmaceuticals business |
| Zdroj: | American journal of rhinologyallergy. 27(2) |
| ISSN: | 1945-8932 |
| Popis: | Background There is a correlation between 18F-fluorodeoxyglucose (FDG) uptake and the level of intracellular metabolic tumor activity, which in turn may be associated with active proliferation, invasion, and prognosis as well as distant metastases in head and neck cancer. This study was designed to assess whether tumor uptake of FDG positron emission tomography (PET) expressed as the maximum standardized uptake value (SUVmax) can be used to predict survival in subjects with paranasal sinus malignancy. Methods We enrolled 42 consecutive subjects with a histological diagnosis of squamous cell carcinoma in paranasal sinus malignancy, into a retrospective institutional imaging trial. Thirty-eight subjects (90.5%) underwent a baseline FDG-PET scan before curative treatment and were eligible for analysis. Results A total of 38 subjects with paranasal sinus malignancy undergoing PET/computed tomography imaging in the initial stages were assessed separately for a potential correlation between SUVmax and T staging, histological grading, and overall survival. Log-rank testing revealed a significant correlation between overall survival and histological grading (p = 0.046); and there was some correlation between SUVmax and histological grading, but not significantly different. The receiver operation characteristic curve was identified for cutoff value of SUVmax as a prognostic factor. We compared the low tumor of the SUVmax group with the high tumor of the SUVmax group divided by the cutoff value of SUVmax. We did find a significant correlation between SUVmax and disease control and mortality (p = 0.003, p < 0.001). Conclusion In our study, we concluded that subjects with higher tumor FDG uptakes should be considered for a more aggressive disease. |
| Databáze: | OpenAIRE |
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