Transcatheter Aortic Valve Replacement in Pure Native Aortic Valve Regurgitation: Challenging Pathology Awaiting Specialized Devices
| Autor: | Adam El-Gamel |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry medicine.medical_treatment medicine.disease Prosthesis Stenosis Aortic valve replacement Valve replacement State-of-the-Art Review Heart failure medicine.artery TAVR for aortic incompetence Ascending aorta cardiovascular system medicine Radiology Nuclear Medicine and imaging Surgery Compassionate Treatment pure native aortic incompetence Cardiology and Cardiovascular Medicine business Aortic valve regurgitation surgical aortic valve replacement |
| Zdroj: | AORTA Journal |
| ISSN: | 2325-4637 |
| DOI: | 10.1055/s-0041-1725122 |
| Popis: | Patients with aortic incompetence frequently present with anatomical and pathological challenges such as elliptical dilated annulus, dilated aortic root, dilated ascending aorta, and with no calcification in the aortic cusps or annulus. Patients are commonly in graver clinical condition as a result of a long silent clinical course before overt congestive heart failure. All of the above make transcatheter therapies for native aortic valve regurgitation more challenging with poorer outcomes, escalating the risk of insufficient anchoring, prosthesis migration, and residual paravalvular leak compared with current transcatheter aortic valve replacement (TAVR) outcomes for aortic stenosis. There is a need for specialized TAVR devices to address this complex pathology. Surgical aortic valve replacement is the current treatment option and the gold standard for patients with aortic incompetence (AR). Currently, the specific off-label indication for TAVR in pure native AR could be a feasible and reasonable option, as a compassionate treatment is limited to inoperable patients and agreed on by the heart team. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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