| Autor: |
Li Huang, Huaqiang Fang, Teng Zhang, Binbin Hu, Shichen Liu, Fanzhen Lv, Zhaoxia Zeng, Huijie Liu, Weimin Zhou, Xiaolei Wang |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Bioactive materials. 23 |
| ISSN: |
2452-199X |
| Popis: |
Drug-eluting balloon (DEB) angioplasty has emerged as an effective treatment for cardiovascular and cerebrovascular diseases. However, distal embolism and late lumen restenosis could be caused by drug loss during DEB handling and rapid drug metabolization. Here, a drug-loaded balloon equipped with tip-separable microneedles on the balloon surface (MNDLB) was developed. Inbuilt near-infrared (NIR) ring laser inside the catheter inner shaft was introduced to activate the biodegradable microneedle tips for the first time. The drug-loaded tips thus could be embedded in the vasculature and then released antiproliferative drug - paclitaxel slowly |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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