Recurrence and Progression of Head and Neck Paragangliomas after Treatment
| Autor: | Valeda Yong, Chandana A. Reddy, Robert R. Lorenz, Kevin J. Contrera, Sara W Liu |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Metastasis Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Paraganglioma Humans Medicine 030223 otorhinolaryngology Head and neck Aged Retrospective Studies Paraganglioma Extra-Adrenal business.industry Incidence Disease progression Middle Aged medicine.disease Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Cohort Disease Progression Female Surgery Radiology Neoplasm Recurrence Local business After treatment |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 162:504-511 |
| ISSN: | 1097-6817 0194-5998 |
| Popis: | To characterize the recurrence of head and neck paragangliomas and the factors associated with disease progression after treatment.Retrospective cohort study.Tertiary care center.In total, 173 adults with 189 paragangliomas (41.3% carotid body, 29.1% glomus jugulare, 19.0% glomus tympanicum, and 10.6% glomus vagale) treated between 1990 and 2010 were evaluated to determine the incidence and risk of recurrence using Cox proportional hazards.The mean (SD) follow-up duration was 8.6 (9.1) years. The incidence was 2.92 recurrences per 100 person-years. The rate of recurrence was 8.2% (95% confidence interval [CI], 3.7-12.7) after 4 years and 17.1% (95% CI, 10.2-24.0) after 10 years. Glomus jugulare tumors were more likely to recur (hazard ratio [HR], 3.69; 95% CI, 1.70-8.01;Recurrence is more common with glomus jugulare tumors and less common with carotid body tumors. Radiation may have a lower risk of recurrence or progression than surgery for some paraganglioma types. Metastasis is rare but more likely with recurrent disease. Surveillance neck imaging is recommended every several years for decades after treatment. |
| Databáze: | OpenAIRE |
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