Raised plasma homocysteine as a risk factor for retinal vascular occlusive disease
| Autor: | Denis C. Shields, Maria Karabatzaki, Per Magne Ueland, Ian D. Graham, Mark Cahill, David J. Mooney, Ray Meleady, Helga Refsum |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Central retinal vein Retinal Artery Occlusion Retinal Artery Cellular and Molecular Neuroscience chemistry.chemical_compound Central retinal vein occlusion Risk Factors Internal medicine Retinal Vein Occlusion medicine Humans Risk factor Homocysteine Aged Retrospective Studies business.industry Vascular disease Retinal Original articles - Clinical science medicine.disease Sensory Systems Surgery Ophthalmology medicine.anatomical_structure chemistry Case-Control Studies Cardiology Branch retinal vein occlusion Female business |
| Zdroj: | British Journal of Ophthalmology. 84:154-157 |
| ISSN: | 0007-1161 |
| Popis: | BACKGROUND/AIMS—A moderately elevated plasma concentration of the sulphur amino acid homocysteine is an independent risk factor for atherosclerotic vascular disease. Many of the risk factors associated with coronary, cerebral, and peripheral atherosclerotic vascular disease are common to retinal vascular occlusive disease but it is unclear whether elevated plasma concentrations of homocysteine are also associated with such disease. This study assessed the relation between retinal vascular occlusive disease and elevated levels of plasma total homocysteine (tHcy). METHODS—A retrospective case-control study involving hospital based controls and cases with retinal artery, central retinal vein (including hemiretinal vein), and branch retinal vein occlusions was performed. The relation between elevated tHcy, defined as a level greater than or equal to 12 µmol/l and risk of retinal vascular occlusive disease was examined. RESULTS—87 cases of retinal vascular occlusive disease including 26 cases of retinal artery occlusion, 40 cases with central retinal vein occlusion, and 21 cases of branch retinal vein occlusion were compared with 87 age matched controls. Mean tHcy levels were higher in all disease groups and this difference was significant in patients with retinal artery occlusions (p= 0.032) and patients with central retinal vein occlusion (p=0.0001). When adjusted for known cardiovascular risk factors, tHcy was an independent risk factor for retinal vascular occlusive disease (OR 2.85 (95% CI 1.43-5.68)). CONCLUSIONS—Elevated tHcy is an independent risk factor for retinal vascular occlusive disease. Assessment of tHcy may be important in the investigation and management of patients with retinal vascular occlusive disease. |
| Databáze: | OpenAIRE |
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