DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos
| Autor: | D. S. Bogolyubov, I. O. Bogolyubova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
X-linked Nuclear Protein
Heterochromatin Chromatin silencing Embryonic Development Review Biology Catalysis Chromatin remodeling Epigenesis Genetic chromatin remodeling Inorganic Chemistry Histones lcsh:Chemistry Death-associated protein 6 Animals Humans Epigenetics Physical and Theoretical Chemistry Molecular Biology Transcription factor lcsh:QH301-705.5 Spectroscopy ATRX Mammals Organic Chemistry heterochromatin General Medicine Computer Science Applications Cell biology Histone genome integrity lcsh:Biology (General) lcsh:QD1-999 biology.protein Oocytes mammalian early development DAXX Female H3.3 chaperones Co-Repressor Proteins Molecular Chaperones |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 1313, p 1313 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | The Death-domain associated protein 6 (DAXX) is an evolutionarily conserved and ubiquitously expressed multifunctional protein that is implicated in many cellular processes, including transcription, cellular proliferation, cell cycle regulation, Fas-induced apoptosis, and many other events. In the nucleus, DAXX interacts with transcription factors, epigenetic modifiers, and chromatin-remodeling proteins such as the transcription regulator ATRX—the α-thalassemia/mental retardation syndrome X-linked ATP-dependent helicase II. Accordingly, DAXX is considered one of the main players involved in chromatin silencing and one of the most important factors that maintain integrity of the genome. In this brief review, we summarize available data regarding the general and specific functions of DAXX in mammalian early development, with special emphasis on the function of DAXX as a chaperone of the histone variant H3.3. Since H3.3 plays a key role in the developmental processes, especially in the pronounced rearrangements of heterochromatin compartment during oogenesis and embryogenesis, DAXX can be considered as an important factor supporting proper development. Specifically, loss of DAXX affects the recruitment of ATRX, transcription of tandem repeats and telomere functions, which results in a decrease in the viability of early embryos. |
| Databáze: | OpenAIRE |
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