Chitinase 3-like 1 is not a target antigen in patients with multiple sclerosis
| Autor: | Júlia Martínez, Manuel Comabella, Peter Schierack, Claudia Deutschmann, Luciana Midaglia, Dirk Roggenbuck, Xavier Montalban |
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| Rok vydání: | 2020 |
| Předmět: |
Multiple Sclerosis
Disease medicine.disease_cause CHI3L1 Autoimmunity Pathogenesis 03 medical and health sciences 0302 clinical medicine Multiple Sclerosis Relapsing-Remitting Medicine Humans 030212 general & internal medicine Chitinase-3-Like Protein 1 biology business.industry Multiple sclerosis Chitinases Autoantibody Multiple Sclerosis Chronic Progressive medicine.disease Neurology Cohort Chitinase Immunology biology.protein Neurology (clinical) business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Multiple sclerosis (Houndmills, Basingstoke, England). 27(9) |
| ISSN: | 1477-0970 |
| Popis: | Autoimmunity to chitinase 3-like 1 (CHI3L1) has recently been reported in hepatic and bowel inflammatory conditions. Considering that CHI3L1 plays a role as prognostic biomarker in multiple sclerosis (MS), here we investigated CHI3L1 as potential autoantigenic target in the disease. We determined serum CHI3L1 autoantibodies by enzyme-linked immunosorbent assay (ELISA) in a cohort of 60 untreated MS patients with different clinical forms of the disease and 20 healthy controls (HC). IgG levels to CHI3L1 were similar between patients with relapsing-remitting MS, primary and secondary progressive MS, and HC. These findings do not support a role for CHI3L1 autoantibodies in MS pathogenesis. |
| Databáze: | OpenAIRE |
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