Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors
| Autor: | Diego Benusiglio, Quirin Krabichler, Valery Grinevich, Arthur Lefevre, Yan Tang, Alexandre Charlet |
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| Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg] |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
anatomy Cognitive Neuroscience Mini Review Neuroscience (miscellaneous) Neuropeptide Neurosciences. Biological psychiatry. Neuropsychiatry Context (language use) Sensory system Biology Feedback 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Neuromodulation oxytocin medicine Premovement neuronal activity Social Behavior Neurons social brain Sensory Systems 030104 developmental biology medicine.anatomical_structure loops Oxytocin nervous system Receptors Oxytocin oxytocin receptor (OTR) [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Neuron Neuroscience 030217 neurology & neurosurgery RC321-571 medicine.drug Social behavior |
| Zdroj: | Frontiers in Neural Circuits Frontiers in Neural Circuits, Vol 15 (2021) Frontiers in Neural Circuits, Frontiers, 2021, 15, ⟨10.3389/fncir.2021.688234⟩ |
| ISSN: | 1662-5110 |
| Popis: | International audience; Oxytocin (OT) is a neuropeptide produced by hypothalamic neurons and is known to modulate social behavior among other functions. Several experiments have shown that OT modulates neuronal activity in many brain areas, including sensory cortices. OT neurons thus project axons to various cortical and subcortical structures and activate neuronal subpopulations to increase the signal-to-noise ratio, and in turn, increases the saliency of social stimuli. Less is known about the origin of inputs to OT neurons, but recent studies show that cells projecting to OT neurons are often located in regions where the OT receptor (OTR) is expressed. Thus, we propose the existence of reciprocal connectivity between OT neurons and extrahypothalamic OTR neurons to tune OT neuron activity depending on the behavioral context. Furthermore, the latest studies have shown that OTR-expressing neurons located in social brain regions also project to other social brain regions containing OTR-expressing neurons. We hypothesize that OTR-expressing neurons across the brain constitute a common network coordinated by OT. |
| Databáze: | OpenAIRE |
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