Ubiquitin-mediated regulation of sterol homeostasis
| Autor: | Dick J. H. van den Boomen, Norbert Volkmar, Paul J. Lehner |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Ubiquitin-Protein Ligases
Familial hypercholesterolemia Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ubiquitin medicine Animals Homeostasis Humans Transcription factor 030304 developmental biology 0303 health sciences Cholesterol Sterol homeostasis Cell Biology medicine.disease Cell biology Sterols Metabolic pathway chemistry Proteolysis HMG-CoA reductase biology.protein Hydroxymethylglutaryl CoA Reductases lipids (amino acids peptides and proteins) 030217 neurology & neurosurgery |
| Zdroj: | Current Opinion in Cell Biology. 65:103-111 |
| ISSN: | 0955-0674 |
| DOI: | 10.1016/j.ceb.2020.04.010 |
| Popis: | Cholesterol is an essential component of mammalian membranes, and its homeostasis is strictly regulated, with imbalances causing atherosclerosis, Niemann Pick disease, and familial hypercholesterolemia. Cellular cholesterol supply is mediated by LDL-cholesterol import and de novo cholesterol biosynthesis, and both pathways are adjusted to cellular demand by the cholesterol-sensitive SREBP2 transcription factor. Cholesterol homeostasis is modulated by a wide variety of metabolic pathways and the ubiquitination machinery, in particular E3 ubiquitin ligases. In this article, we review recent progress in understanding the role of E3 ubiquitin ligases in the metabolic control of cellular sterol homeostasis. |
| Databáze: | OpenAIRE |
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