Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France

Autor: Audrey Giraud-Gatineau, Stéphane Honoré, Philippe Parola, Hervé Tissot-Dupont, Yanis Roussel, Jean-Christophe Lagier, Eric Chabrière, Yolande Obadia, Carole Eldin, Didier Raoult, Morgane Mailhe, Florence Fenollar, Philippe Brouqui, Anthony Levasseur, Bernard La Scola, Michel Drancourt, Andreas Stein, Nadim Cassir, Jean-Marc Rolain, Jean Claude Deharo, Christine Zandotti, Vera Esteves-Vieira, Sophie Amrane, Camille Aubry, Catherine Dhiver, Alexis Jacquier, Piseth Seng, Pierre-Edouard Fournier, Christelle Tomei, Philippe Colson, Isabelle Ravaux, Marie Hocquart, Barbara Doudier, Cyril Berenger, Florian Correard, Matthieu Million, Philippe Gautret
Přispěvatelé: Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Département de Radiologie [Hôpital de la Timone - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Time Factors
[SDV]Life Sciences [q-bio]
Azithromycin
Polymerase Chain Reaction
0302 clinical medicine
Belgium
Case fatality rate
030212 general & internal medicine
Young adult
ComputingMilieux_MISCELLANEOUS
Aged
80 and over
Middle Aged
Viral Load
Treatment Outcome
Infectious Diseases
Drug Therapy
Combination
Female
France
Coronavirus Infections
Viral load
medicine.drug
Hydroxychloroquine
Adult
medicine.medical_specialty
Adolescent
030231 tropical medicine
Pneumonia
Viral
Antiviral Agents
Article
03 medical and health sciences
Betacoronavirus
Young Adult
Internal medicine
medicine
Humans
Viral shedding
Pandemics
Aged
Retrospective Studies
business.industry
SARS-CoV-2
Public Health
Environmental and Occupational Health
COVID-19
Retrospective cohort study
COVID-19 Drug Treatment
Regimen
business
Follow-Up Studies
Zdroj: Travel Medicine and Infectious Disease
Travel Medicine and Infectious Disease, 2020, 35, pp.101738. ⟨10.1016/j.tmaid.2020.101738⟩
ISSN: 1477-8939
DOI: 10.1016/j.tmaid.2020.101738
Popis: Background In France, the combination hydroxychloroquine (HCQ) and azithromycin (AZ) is used in the treatment of COVID-19. Methods We retrospectively report on 1061 SARS-CoV-2 positive tested patients treated with HCQ (200 mg three times daily for ten days) + AZ (500 mg on day 1 followed by 250 mg daily for the next four days) for at least three days. Outcomes were death, clinical worsening (transfer to ICU, and >10 day hospitalization) and viral shedding persistence (>10 days). Results A total of 1061 patients were included in this analysis (46.4% male, mean age 43.6 years – range 14–95 years). Good clinical outcome and virological cure were obtained in 973 patients within 10 days (91.7%). Prolonged viral carriage was observed in 47 patients (4.4%) and was associated to a higher viral load at diagnosis (p
Databáze: OpenAIRE
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