Chlamydia trachomatis as a Cause of Neonatal Conjunctivitis in Dutch Infants
| Autor: | Ronald de Groot, Roel P Verkooyen, Alewijn Ott, Ingrid G I J G Rours, Tjeerd J T H N De Faber, Margaret R. Hammerschlag, Henri A Verbrugh |
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| Přispěvatelé: | Medical Microbiology & Infectious Diseases, Pediatrics |
| Rok vydání: | 2008 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Microbiological culture Administration Topical Population Chlamydia trachomatis medicine.disease_cause Auto-immunity transplantation and immunotherapy [N4i 4] Neonatal conjunctivitis Humans Medicine Prospective Studies education Netherlands Retrospective Studies Bacterial Conjunctivitis education.field_of_study Chlamydia business.industry Poverty-related infectious diseases [N4i 3] Infant Newborn Mucopurulent discharge Conjunctivitis Inclusion medicine.disease Anti-Bacterial Agents Pathogenesis and modulation of inflammation [N4i 1] Pneumonia Pediatrics Perinatology and Child Health Female Microbial pathogenesis and host defense [UMCN 4.1] medicine.symptom business |
| Zdroj: | Pediatrics (Evanston), 121, e321-6 Pediatrics (Evanston), 121, 2, pp. e321-6 Pediatrics, 121(2), 321-326. American Academy of Pediatrics |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.2007-0153 |
| Popis: | BACKGROUND. Chlamydia trachomatis is the most common sexually transmitted pathogen in adults, which at delivery may be transmitted from mother to child and cause conjunctivitis and pneumonia. In the Netherlands, prenatal chlamydial screening and treatment of pregnant women is not routine practice. The contribution of C trachomatis to neonatal ophthalmic disease has not been studied in the Netherlands and remains unclear. METHODS. At the Sophia Children's Hospital and Rotterdam Eye Hospital, 2 cohorts of infants RESULTS. C trachomatis was detected in 27 (64%) of 42 retrospectively studied infants and 14 (61%) of 23 prospectively studied infants. Mucopurulent discharge was present in 35 (95%) of 37, swelling of the eyes in 27 (73%) of 37, conjunctival erythema in 24 (65%) of 37, respiratory symptoms in 14 (38%) of 37, and feeding problems in 5 (14%) of 37 infants respectively. Before microbiological diagnosis, general practitioners prescribed antichlamydial antibiotics locally to 5 (12%) of 41 and systemically to 4 (10%) of 41 infants who tested positive for chlamydia, and ophthalmologists prescribed to 21 (51%) of 41 and 7 (17%) of 41, respectively. CONCLUSIONS. C trachomatis was the major cause of bacterial conjunctivitis in this population. Clinically, differentiation from other pathogens was not possible. Many infants who tested positive for chlamydia did not receive appropriate antibiotic treatment. |
| Databáze: | OpenAIRE |
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