Two different mechanisms in patients with venous thrombosis and defective fibrinolysis: low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor
| Autor: | H Ljungnér, L Tengborn, Inga Marie Nilsson |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Tissue plasminogen activator Fibrin Plasminogen Activators Internal medicine Fibrinolysis Plasminogen Inactivators medicine Humans General Environmental Science Blood coagulation test Aged Glycoproteins biology business.industry General Engineering General Medicine Middle Aged Thrombophlebitis medicine.disease Thrombosis Venous thrombosis Endocrinology Vasoconstriction Immunology biology.protein General Earth and Planetary Sciences Female Blood Coagulation Tests business Plasminogen activator medicine.drug Research Article |
| Zdroj: | British medical journal (Clinical research ed.). 290(6480) |
| ISSN: | 0267-0623 |
| Popis: | Fibrinolytic components after venous occlusion and concentrations of tissue plasminogen activator inhibitor were studied in 100 consecutive patients with confirmed recurrent deep vein thrombosis or pulmonary embolism. After 20 minutes of venous occlusion the fibrinolytic response was decreased in 33 patients, as measured both amidolytically with S-2251 and on fibrin plates. Two different mechanisms responsible for the poor fibrinolytic response could be distinguished. Twenty two of the patients in whom the response was poor released normal amounts of tissue plasminogen activator antigen, as assayed by immunoradiometric assay, but had appreciably increased concentrations of tissue plasminogen activator inhibitor. The 11 other patients in whom the response was poor had both low tissue plasminogen activator activities and low tissue plasminogen activator antigen concentrations but normal concentrations of tissue plasminogen activator inhibitor. The results show not only that defective synthesis or release of tissue plasminogen activator may be important in the pathogenesis of venous thrombosis but also that a large group of patients with thrombosis have an increased concentration of the inhibitor to tissue plasminogen activator. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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