Exploring the Impact of Morphology on the Properties of Biodegradable Nanoparticles and Their Diffusion in Complex Biological Medium
| Autor: | Roxane Ridolfo, Jan C. M. van Hest, Shirin Tavakoli, Vijayabhaskarreddy Junnuthula, David S. Williams, Arto Urtti |
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| Přispěvatelé: | Bio-Organic Chemistry, Institute for Complex Molecular Systems, ICMS Business Operations, ICMS Core, Drug Delivery Unit, Division of Pharmaceutical Biosciences, Drug Research Program, Pharmaceutical Nanotechnology, Doctoral Programme in Drug Research, Divisions of Faculty of Pharmacy, University of Helsinki, Drug Delivery |
| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
Polymers 116 Chemical sciences LIPOSOMES Nanoparticle Bioengineering Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Micelle Article DISEASE Biomaterials Drug Delivery Systems Amphiphile Materials Chemistry Copolymer PARTICLES Solubility Micelles Drug Carriers Liposome Chemistry MACULAR DEGENERATION 021001 nanoscience & nanotechnology 0104 chemical sciences SIZE TARGET ANIMAL-MODELS 317 Pharmacy Drug delivery Polymersome Nanoparticles SHAPE 0210 nano-technology RELEASE KINETICS |
| Zdroj: | Biomacromolecules, 22(1), 126-133. American Chemical Society Biomacromolecules |
| ISSN: | 1526-4602 1525-7797 |
| Popis: | Nanoparticle morphology (size, shape, and composition) and surface chemistry are the determining factors underpinning the efficacy of such materials in therapeutic applications. The size, shape, and surface chemistry of a nanoparticle can strongly influence key properties such as interactions with diverse biological fluids and interfaces and, in turn, impact the delivery of bioactive cargo, modulating therapeutic performance. This is exemplified in ocular drug delivery, where potential therapeutics must navigate complex biological media such as the gel-like vitreal fluid and the retina. Biodegradable block copolymer amphiphiles are a robust tool for the engineering of various types of self-assembled nanoparticles with diverse morphologies ranging from spherical and tubular polymersomes to spherical and worm-like micelles. Here, we explore the effect of morphological features such as shape and surface chemistry upon the interactions of a series of copolymer nanoparticles with retinal (ARPE-19) cells and the release of a low solubility drug (dexamethasone) that is currently used in ocular therapy and study their diffusion in vitreous using ex vivo eyes. We demonstrate that both aspect ratio and surface chemistry of nanoparticles will influence their performance in terms of cell uptake, drug release, and diffusion with high aspect ratio shapes demonstrating enhanced properties in relation to their spherical counterparts. |
| Databáze: | OpenAIRE |
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