Candida glabrata and Candida albicans; dissimilar tissue tropism and infectivity in a gnotobiotic model of mucosal candidiasis
| Autor: | David A. Schofield, Caroline Westwater, Peter J. Nicholas, Edward Balish, Emily E. Paulling |
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| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
T-Lymphocytes Immunology Candida glabrata Microbiology Tropism Mice Esophagus Candidiasis Oral Candida albicans medicine Gastric mucosa Immunology and Allergy Animals Germ-Free Life Infectivity biology Candidiasis Mouth Mucosa General Medicine medicine.disease biology.organism_classification digestive system diseases Corpus albicans Killer Cells Natural Mice Inbred C57BL Infectious Diseases medicine.anatomical_structure Gastric Mucosa Tissue tropism Mice Inbred CBA Systemic candidiasis |
| Zdroj: | FEMS immunology and medical microbiology. 51(1) |
| ISSN: | 0928-8244 |
| Popis: | Germ-free transgenic epsilon 26 (Tgepsilon26) mice, deficient in both natural killer (NK)- and T-cells, were inoculated (orally) with each of two Candida glabrata (BG2 or BG1003) or Candida albicans (CAF2-1 or SC5314) strains. Candida glabrata- or C. albicans-colonized mice exhibited similar numbers of viable Candida in the alimentary tract. Neither C. glabrata nor C. albicans caused systemic candidiasis of endogenous (alimentary tract) origin. Candida albicans invaded oroesophageal (tongue, palate, esophagus) and keratinized gastric tissues, evoked hyperkeratosis and a prominent, chronic, granulocyte-dominated, inflammatory response in all infected tissues, stimulated the production of splenic granulocytes and was lethal for the mice within 3-5 weeks after oral colonization. The two C. glabrata strains colonized the alimentary tract and penetrated into the keratinized (cardia-antrum) gastric tissues, but in contrast to C. albicans, were unable to infect oroesophageal tissues. Furthermore, C. glabrata strains were not lethal for the Tgepsilon26 mice, and did not evoke an inflammatory response in colonized gastric tissues or stimulate the production of splenic granulocytes. This 'stealth-like' behavior could explain the ability of C. glabrata to persist in infected tissues and survive as a commensal in the alimentary tract. |
| Databáze: | OpenAIRE |
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