Design and structure-activity relationship of heterocyclic analogs of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones as inhibitors of receptor tyrosine kinases

Autor:	Cynthia M. Shafer, Jayesh Vora, Gena Lapointe, Sabina Pecchi, Kelly A. Frazier, Paul A. Renhowe, Marion Wiesmann, Clarke Taylor, Christopher McBride, Jazan Elisa, Dirksen E. Bussiere, Molly Min He, Sylvia Ma, Johanna M. Jansen
Rok vydání:	2005
Předmět:	Platelet-derived growth factor Stereochemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Chemical synthesis Receptor tyrosine kinase chemistry.chemical_compound Structure-Activity Relationship Heterocyclic Compounds Drug Discovery Structure–activity relationship Enzyme Inhibitors Molecular Biology chemistry.chemical_classification biology Organic Chemistry Receptor Protein-Tyrosine Kinases In vitro Hydroquinones Enzyme chemistry Cell culture Drug Design biology.protein Molecular Medicine Benzimidazoles Signal transduction
Zdroj:	Bioorganicmedicinal chemistry letters. 16(8)
ISSN:	0960-894X
Popis:	Herein are described a series of novel heterocyclic analogs of the 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one scaffold. These compounds are potent inhibitors of receptor tyrosine kinases and exhibit favorable pharmacokinetic profiles. The synthesis and SAR of these compounds are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1cc5ce2fc3d52759ee562d906188b4 https://pubmed.ncbi.nlm.nih.gov/16446087 Zobrazit plný text záznamu Full Text from ScienceDirect