Novel 2-Aminotetralin and 3-AminoChroman Derivatives as Selective Serotonin 5-HT7 Receptor Agonists and Antagonists
| Autor: | Sverker Hanson, Rolf Johansson, Robert Leideborg, Nina Mohell, Susanne Rosqvist, Pär Holmberg, Patrizia Caldirola, Anette M. Johansson, Daniel Sohn, Gunnar Nordvall, Pavel Zlatoidsky |
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| Rok vydání: | 2004 |
| Předmět: |
Agonist
Tetrahydronaphthalenes Tertiary amine medicine.drug_class CHO Cells Ligands Serotonergic 5-HT7 receptor Structure-Activity Relationship Cricetinae Drug Discovery Cyclic AMP medicine Animals Selective receptor modulator Chromans Receptor Chemistry Stereoisomerism Serotonin Receptor Agonists Biochemistry Receptors Serotonin Molecular Medicine Serotonin Antagonists Serotonin Endogenous agonist |
| Zdroj: | Journal of Medicinal Chemistry. 47:3927-3930 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | The understanding of the physiological role of the G-protein coupled serotonin 5-HT(7) receptor is largely rudimentary. Therefore, selective and potent pharmacological tools will add to the understanding of serotonergic effects mediated through this receptor. In this report, we describe two compound classes, chromans and tetralins, encompassing compounds with nanomolar affinity for the 5-HT(7) receptor and with good selectivity. Within theses classes, we have discovered both agonists and antagonists that can be used for further understanding of the pharmacology of the 5-HT(7) receptor. |
| Databáze: | OpenAIRE |
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