The biological activity and tissue distribution of 2',3'-dihydrophylloquinone in rats
| Autor: | Hiroshi Harada, Yosuke Isobe, Sanshiroh Saitoh, Yusuke Hara, Satoru Konishi, Toshiro Sato, Shuichi Kamo, Rumi Ozaki |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Vitamin
Male medicine.medical_specialty Sodium Osteocalcin Biophysics chemistry.chemical_element Biology Biochemistry Cofactor Rats Sprague-Dawley chemistry.chemical_compound Internal medicine medicine Animals heterocyclic compounds Tissue Distribution Molecular Biology Kidney Biological activity Vitamin K 1 Rats medicine.anatomical_structure Endocrinology Coagulation chemistry biology.protein Pancreas |
| Zdroj: | Biochimica et biophysica acta. 1622(3) |
| ISSN: | 0006-3002 |
| Popis: | 2',3'-Dihydrophylloquinone (dihydro-K1) is a hydrogenated form of vitamin K1 (K1), which is produced during the hydrogenation of K1-rich plant oils. In this study, we found that dihydro-K1 counteracts the sodium warfarin-induced prolonged blood coagulation in rats. This indicates that dihydro-K1 functions as a cofactor in the posttranslational gamma-carboxylation of the vitamin K-dependent coagulation factors. It was also found that dihydro-K1 as well as K1 inhibits the decreasing effects of warfarin on the serum total osteocalcin level. In rats, dihydro-K1 is well absorbed and detected in the tissues of the brain, pancreas, kidney, testis, abdominal aorta, liver and femur. K1 is converted to menaquinone-4 (MK-4) in all the above-mentioned tissues, but dihydro-K1 is not. The unique characteristic of dihydro-K1 possessing vitamin K activity and not being converted to MK-4 would be useful in revealing the as yet undetermined physiological function of the conversion of K1 to MK-4. |
| Databáze: | OpenAIRE |
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