Characteristics of Women with Dysplasia or Carcinoma in Situ of the Cervix Uteri
| Autor: | R. H. Cowdell, L. A. Brinton, Pete Smith, R. W. C. Harris, Richard Doll, Martin Vessey, D.C.G. Skegg |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Risk Mild Dysplasia Cancer Research First intercourse medicine.medical_specialty Adolescent Alcohol Drinking Sexual Behavior Population Uterine Cervical Neoplasms Pregnancy Uterine Cervical Dysplasia Humans Medicine education Child Cervix Gynecology Cervical cancer education.field_of_study Invasive carcinoma business.industry Obstetrics Carcinoma in situ Smoking Coitus Obstetrics and Gynecology Histology General Medicine Middle Aged medicine.disease Contraception medicine.anatomical_structure Oncology England Social Class Dysplasia Female business Carcinoma in Situ Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0029-7828 0007-0920 |
| DOI: | 10.1097/00006254-198201000-00021 |
| Popis: | To identify risk factors for various cervical abnormalities, 237 women with abnoromal cervical smears and 422 control women were interviewed. Cervical biopsy specimens taken from the patients with abnormal smears were reviewed according to standard criteria by one pathologist and classified as follows: 65 carcinoma in situ, 81 severe dysplasia, 44 mild dysplasia and 47 normal histology. Factors associated with risk of mild dysplasia, severe dysplasia and carcinoma in situ were similar to those previously identified for invasive carcinoma, and included age at first intercourse, multiple sexual partners and pregnancy outside marriage. Analysis to disentangle correlated factors revealed that number of sexual partners exerted effects independently of age at first intercourse, whereas the reverse was not true. This finding fails to support suggestions that adolescence is a period when the cervix is most vulnerable to the effects of sexual behaviour. Other factors relating to risk of cervical abnormalities were smoking and use of oral contraceptives. It was not possible to show that these relationships were incidental, but further investigation is required to establish whether they are causal. |
| Databáze: | OpenAIRE |
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