EVALUATION OF A PDLLA/45S5 BIOGLASS COMPOSITE: MECHANICAL AND BIOLOGICAL PROPERTIES
| Autor: | Zenati Rachid, Ginsac Nathalie, Chenal Jean Marc, Chevalier Jérôme, Hartmann Daniel, Meille Sylvain |
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| Přispěvatelé: | Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Narayan, R and Colombo, Mateis, Laboratoire, Narayan, R and Colombo, P |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Materials science
Simulated body fluid Composite number 02 engineering and technology [SPI.MAT] Engineering Sciences [physics]/Materials 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences [SPI.MAT]Engineering Sciences [physics]/Materials Differential scanning calorimetry Biological property X-ray crystallography Composite material 0210 nano-technology |
| Zdroj: | ADVANCES IN BIOCERAMICS AND POROUS CERAMICS II ADVANCES IN BIOCERAMICS AND POROUS CERAMICS II, 2010, 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA, Unknown Region. pp.95 HAL Advances in Bioceramics and Porous Ceramics II |
| Popis: | 33rd International Conference on Advanced Ceramics and Composites, Daytona Beach, FL, JAN 18-23, 2009; International audience; The present study aims to characterize a composite made of poly-L,DL-lactic acid (P(L,DL)LA, Mv: 120 KDa) containing 30 wt% of 45S5 bioactive glass particles. Glass transition (around 52 degrees C) of the polymer was assessed by differential scanning calorimetry (DSC). The mechanical properties of the neat polymer and the composite were evaluated by tensile and compressive tests. From these tests, it was confirmed that the addition of bioglass into the polymer matrix leads to a slight decrease in tensile strength and an increase in elastic modulus. In vitro bioactivity of this composite was evaluated by immersion in a simulated body fluid (SBF) at 37 degrees C for different durations. Formation of hydroxyapatite crystals on the surface of the composite was recorded by scanning electron microscopy and confirmed by X-ray diffraction. Many hydroxyapatite crystals covered the surface of the composite after 14 days of immersion in simulated body fluid. Osteoblast cells MG-63 (human osteosarcoma cell line) were cultured in direct contact with the polymer and the composite. Cells morphology and attachment were analysed using SEM and MTT viability test. Scanning electron microscopy analysis showed the presence of cells at the surface of the composite. These results confirmed the biocompatibility of the composite and the positive effect of the bioglass on the osteoblast cells adhesion and proliferation on the composite. |
| Databáze: | OpenAIRE |
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