Secreted Forms of β-Amyloid Precursor Protein Protect Against Ischemic Brain Injury
| Autor: | Susan D. Craddock, Russell E. Rydel, Virginia L. Smith-Swintosky, L. Creed Pettigrew, Mark P. Mattson, Alan R. Culwell |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Ischemia Kidney Transfection Hippocampus Biochemistry Neuroprotection Cell Line Cerebral Ventricles Stereotaxic Techniques Amyloid beta-Protein Precursor Cellular and Molecular Neuroscience In vivo mental disorders Amyloid precursor protein medicine Extracellular Animals Humans Rats Wistar Injections Intraventricular Neurons biology Chemistry Pyramidal Cells P3 peptide Brain Serum Albumin Bovine medicine.disease Recombinant Proteins Rats Cell biology Biochemistry of Alzheimer's disease Ischemic Attack Transient biology.protein Amyloid precursor protein secretase Neuroscience |
| Zdroj: | Journal of Neurochemistry. 63:781-784 |
| ISSN: | 1471-4159 0022-3042 |
| DOI: | 10.1046/j.1471-4159.1994.63020781.x |
| Popis: | The beta-amyloid precursor protein (beta APP) is the source of the amyloid beta-peptide that accumulates in the brain in Alzheimer's disease. A major processing pathway for beta APP involves an enzymatic cleavage within the amyloid beta-peptide sequence that liberates secreted forms of beta APP (APPss) into the extracellular milieu. We now report that postischemic administration of these APPss intracerebroventricularly protects neurons in the CA1 region of rat hippocampus against ischemic injury. Treatment with APPs695 or APPs751 resulted in increased neuronal survival, and the surviving cells were functional as demonstrated by their ability to synthesize protein. These data provide direct evidence for a neuroprotective action of APPss in vivo. |
| Databáze: | OpenAIRE |
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