Changes in QRS and T-wave Loops Subsequent to an Increase in Left Ventricle Globularity as in Intrauterine Growth Restriction: a Simulation Study
| Autor: | Nuria Ortigosa, Konstantinos A. Mountris, Ana Mincholé, Pablo Laguna, Freddy L. Bueno-Palomeque, Raquel Bailon, Esther Pueyo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Chemistry 0206 medical engineering Intrauterine growth restriction 02 engineering and technology 030204 cardiovascular system & hematology medicine.disease 020601 biomedical engineering 03 medical and health sciences QRS complex Electrophysiology 0302 clinical medicine medicine.anatomical_structure In vivo Ventricle Internal medicine cardiovascular system medicine Cardiology In vivo measurements cardiovascular diseases MATEMATICA APLICADA |
| Zdroj: | CinC RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname 2020 Computing in Cardiology Conference (CinC) |
| ISSN: | 2325-887X |
| DOI: | 10.22489/cinc.2020.438 |
| Popis: | [EN] Cardiovascular remodeling induced by intrauterine growth restriction manifests in adulthood by more globular ventricles, as evidenced by in vivo measurements. The angle between the dominant vectors of the QRS and T-wave loops has been reported to be significantly altered as a result of the induced remodeling. To investigate whether the more globular ventricular shape was a major factor contributing to such alteration, we performed electrophysiological simulations in a human biventricular model for control and in a model obtained by deforming the control one to represent a more spherical left ventricle (SLV). Transmural ventricular heterogeneities and a Purkinje network were included. 12-lead ECGs were calculated, from which spatial QRS and T-wave angles were computed. The angle between the T-wave and the XZ-plane was found to increase in the SLV model, showing a variation similar to that reported in in vivo studies. However, the angle between the dominant vectors of the QRS and T-wave loops projected onto the XY-plane was lower for control, contrary to clinical observations in IUGR adults. Other clinical results could not be reproduced in our simulations either. Our findings suggest that a more globular left ventricular shape leads to changes in the angles of QRS and T-wave loops, but further research is needed to fully understand these changes and the underlying mechanisms I would like to acknowledge support by Fundaci ' on Carolina, Universidad de Zaragoza and Universidad Polit ' ecnica Salesiana through its doctoral scholar-ship. This work was supported by projects ERC-StG 638284 (ERC), PID2019-105674RB-I00 and PID2019104881RB-I00 (MICINN) and LMP124-18 and reference group T39-20R (Arag ' on Government cofunded by FEDER 2014-2020 "Building Europe from Aragon"). Computations were performed using ICTS NANBIOSIS (HPC unit at U. Zaragoza). N. Ortigosa acknowledges support from Generalitat Valenciana under grant Prometeo/2017/102 and Spanish MINECO under grant MTM2016-76647-P |
| Databáze: | OpenAIRE |
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