Circulating leptin and cortisol after burn injury: loss of diurnal pattern

Autor: Kristina G. Hobson, Mary Beth Lawless, Addison L. McMurtry, David D. Greenhalgh, Tina L Palmieri, Peter J. Havel
Rok vydání: 2004
Předmět:
Leptin
Blood Glucose
Male
Burn injury
Hydrocortisone
medicine.medical_treatment
Body Mass Index
Insulin
2.1 Biological and endogenous factors
Child
General Nursing
media_common
Rehabilitation
Middle Aged
Circadian Rhythm
Child
Preschool
General Health Professions
Emergency Medicine
Female
medicine.symptom
Burns
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Adult
medicine.medical_specialty
Adolescent
media_common.quotation_subject
Clinical Sciences
Radioimmunoassay
Anorexia
Metabolic and Endocrine
Insulin resistance
Clinical Research
Internal medicine
medicine
Humans
Obesity
Preschool
Aged
Nutrition
business.industry
Appetite
medicine.disease
Emergency & Critical Care Medicine
Endocrinology
Case-Control Studies
Injury (total) Accidents/Adverse Effects
Surgery
business
Hormone
Zdroj: The Journal of burn care & rehabilitation, vol 25, iss 6
Hobson, Kristina G; Havel, Peter J; McMurtry, Addison L; Lawless, Mary Beth; Palmieri, Tina L; & Greenhalgh, David D. (2004). Circulating leptin and cortisol after burn injury: loss of diurnal pattern.. The Journal of burn care & rehabilitation, 25(6), 491-499. doi: 10.1097/01.bcr.0000144532.02792.6e. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4269x2z1
DOI: 10.1097/01.bcr.0000144532.02792.6e.
Popis: Leptin, a hormone involved in appetite and metabolic energy expenditure, could have a role in the reduced appetite and/or energy expenditure after burn injury. In this study, the diurnal pattern of circulating leptin concentrations was compared with body mass index (BMI), sex, glucose, insulin, and the diurnal cortisol rhythm in burn patients. Plasma samples were collected at 12:00 pm and 02:00 am from severely burned adults and children. Circulating leptin, insulin, and cortisol were measured by radioimmunoassay. Results were compared with previously published data from healthy control subjects. Overall, plasma leptin levels were lower in burn patients (5.7 ± 1.2 ng/mL) compared with control subjects (10.5 ± 1.7 ng/mL, P = .02). The normal nocturnal increase of circulating leptin concentrations observed in control subjects was completely absent in burn patients. Cortisol levels were higher in burn patients (20.4 ± 1.0 mg/dL) than in control subjects (9.8 ± 1.6mg/dL, P < .0001) and the normal circadian decrease of circulating cortisol levels was markedly blunted in burn patients. Plasma cortisol did not correlate with circulating leptin levels. Plasma insulin and plasma glucose levels were significantly elevated in burn patients and the insulin:glucose ratio was dramatically increased compared with control subjects. Patients with burn injuries exhibited significantly decreased circulating leptin levels. This decrease may be the result of marked insulin resistance, as suggested by the elevated insulin to glucose ratio in burn patients. The loss of the diurnal pattern in burn patients is likely to result from the continuous nutritional supplementation. Because low leptin levels should induce appetite, burn-related anorexia is probably controlled by other regulatory systems.
Databáze: OpenAIRE
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