Dimeric W3SO3 Cluster Complexes: Synthesis, Characterization, and Potential Applications as X-ray Contrast Agents
| Autor: | Alan D. Watson, Brent Segal, Tony Sanderson, Sandya Suravajjala, Shannan L. Downey, Bacon Edward R, Shi-Bao Yu, Daniel Joseph Nycomed Amersham Imaging Delecki, Michael Droege, William Newcomb, Earley William, Shaun P. Crofts |
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| Rok vydání: | 2001 |
| Předmět: |
Models
Molecular Medical diagnostic Magnetic Resonance Spectroscopy Molecular Structure Stereochemistry Chemistry X-Rays X-ray Contrast Media In Vitro Techniques Tungsten Compounds Crystallography X-Ray Rats Characterization (materials science) Inorganic Chemistry Metal Crystallography visual_art visual_art.visual_art_medium Cluster (physics) Animals Physical and Theoretical Chemistry Dimerization |
| Zdroj: | Inorganic Chemistry. 40:1576-1581 |
| ISSN: | 1520-510X 0020-1669 |
| DOI: | 10.1021/ic0001053 |
| Popis: | Our continued research on the use of heavy metal cluster complexes as a new class of X-ray contrast agents in medical diagnostic imaging is described. A series of 2:3 cluster-ligand complexes, [(W(IV)3SO3)2L3]4- (L = linear polyaminopolycarboxylate ligands), were isolated from the reaction of aqua ion [W(IV)3SO3(H2O)9]4- (prepared in large quantities through an improved literature process) with respective ligands in refluxing DMF. The salts of [(W(IV)3SO3)2L3]4- complex anions were fully characterized using routine techniques such as elemental analysis, MS, HPLC, UV-vis, IR, and NMR. The solid structures of two complex anions, [(W(IV)3SO3)2(PDTA)3]4- and [(W(IV)3SO3)2(HO-PDTA)3]4-, were determined by X-ray crystallography. They are the first examples wherein two W(IV)3SO3 clusters are complexed and linked by three ligands that contain two terminal iminodiacetate (bis-IDA) groups. Complexation of the unstable aqua ion [W(IV)3SO3(H2O)9]4- with ligands has imparted desired biological compatibility to the tungsten metal cluster. These complexes are stable and highly soluble in H2O. The potential utility of such tungsten cluster complexes as X-ray contrast agents was evaluated in both in vitro and in vivo animal studies. In addition, the syntheses of several new linear polyaminopolycarboxylate ligands used in this study are reported. |
| Databáze: | OpenAIRE |
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