Effect of Synthetic Progestogens and Estradiol-17β on Adrenal Function in the Rat

Autor: J. G. Rochefort, M. L. Givner
Rok vydání: 1972
Předmět:
Zdroj: Endocrinology. 90:1238-1244
ISSN: 1945-7170
0013-7227
DOI: 10.1210/endo-90-5-1238
Popis: Medroxyprogesterone acetate, chlormadinone acetate, AY-11,497 and clogestone acetate (AY-11,440) reduced adrenal and ovarian weights, serum and adrenal corticosterone in the rat. Adrenal homogenates from rats treated with medroxyprogesterone acetate showed impaired capacity to convert progesterone (IIβ- and/or 21 -hydroxylation) and 11β-hydroxyprogesterone (21-hydroxylation) to corticosterone. In vitro, medroxyprogesterone acetate and clogestone acetate (1 × 10-4M) did not affect the conversion of progesterone to corticosterone. Estradiol-17β treatment enhanced the conversion of progesterone to corticosterone by adrenal homogenates from most progestogen treated rats, and the conversion of 11β-hydroxyprogesterone to corticosterone by adrenal homogenates from rats treated with medroxyprogesterone acetate. (Endocrinology 90: 1238, 1972)
Databáze: OpenAIRE
Pro tento záznam nejsou dostupné žádné jednotky.