Tcf1+ cells are required to maintain the inflationary T cell pool upon MCMV infection
| Autor: | Nathalie Oetiker, Ioana Sandu, Alessandro Pedrioli, Alexander Yermanos, Nicolas S. Baumann, Werner Held, Jennifer D. Oduro, Franziska Wagen, Sai T. Reddy, Annette Oxenius, Suzanne P. M. Welten, Luka Cicin-Sain |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Science T cell Population General Physics and Astronomy Biology T cell response General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine medicine Animals CD8-Positive T-Lymphocytes/immunology Cell Proliferation Clone Cells Herpesviridae Infections/immunology Herpesviridae Infections/virology Immunologic Memory Interferon Type I/metabolism Interleukin-12/metabolism Mice Inbred C57BL Muromegalovirus/physiology Phenotype T Cell Transcription Factor 1/metabolism T-Lymphocytes/immunology T-Lymphocytes/virology Cytotoxic T cell lcsh:Science education Transcription factor Viral reactivation education.field_of_study Multidisciplinary T-cell receptor General Chemistry 3. Good health Cell biology Vaccination 030104 developmental biology medicine.anatomical_structure lcsh:Q 030215 immunology |
| Zdroj: | Nature communications England Nature Communications, 11 (1) Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020) Nature communications, vol. 11, no. 1, pp. 2295 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-16219-3 |
| Popis: | Cytomegalovirus-based vaccine vectors offer interesting opportunities for T cell-based vaccination purposes as CMV infection induces large numbers of functional effector-like cells that accumulate in peripheral tissues, a process termed memory inflation. Maintenance of high numbers of peripheral CD8 T cells requires continuous replenishment of the inflationary T cell pool. Here, we show that the inflationary T cell population contains a small subset of cells expressing the transcription factor Tcf1. These Tcf1+ cells resemble central memory T cells and are proliferation competent. Upon sensing viral reactivation events, Tcf1+ cells feed into the pool of peripheral Tcf1− cells and depletion of Tcf1+ cells hampers memory inflation. TCR repertoires of Tcf1+ and Tcf1− populations largely overlap, with the Tcf1+ population showing higher clonal diversity. These data show that Tcf1+ cells are necessary for sustaining the inflationary T cell response, and upholding this subset is likely critical for the success of CMV-based vaccination approaches. |
| Databáze: | OpenAIRE |
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