Peripheral blood Leptin and Resistin levels as clinical activity biomarkers in Mexican Rheumatoid Arthritis patients
| Autor: | Sandra Carrillo-Vázquez, Carolina Bustos Rivera-Bahena, José Luis Montiel-Hernández, Judith González-Christen, Daniel-Xavier Xibillé-Friedmann |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Leptin Male 0301 basic medicine medicine.medical_specialty Adolescent medicine.medical_treatment Adipokine Enzyme-Linked Immunosorbent Assay Severity of Illness Index Proinflammatory cytokine Arthritis Rheumatoid Young Adult 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Humans Resistin Mexico Aged 030203 arthritis & rheumatology Adiponectin business.industry nutritional and metabolic diseases General Medicine Middle Aged medicine.disease Cross-Sectional Studies 030104 developmental biology Endocrinology Cytokine Antirheumatic Agents Rheumatoid arthritis Immunology Cytokines Female Tumor necrosis factor alpha business Biomarkers hormones hormone substitutes and hormone antagonists |
| Zdroj: | Reumatología Clínica (English Edition). 12:323-326 |
| ISSN: | 2173-5743 |
| DOI: | 10.1016/j.reumae.2016.10.001 |
| Popis: | Objective To evaluate the association between the clinical activity of RA patients and serum adipocytokines (Leptin, Adiponectin and Resistin) and inflammatory cytokines. Methods All RA patients fulfilled ACR 1987 criteria and were treated with DMARDs. Adipocytokine and inflammatory cytokine levels were evaluated using ELISA. Results 121 patients were included in the study. Stratifying according to DAS28 (low, moderate and high activity), there were significant differences for Leptin, Resistin, IL-6 and IL-17, however, no differences were seen for Adiponectin, TNFα or IL-1β. Clinical activity positively correlated with Leptin, Resistin, IL-17 and IL-6 levels, but not with Adiponectin, TNFα or IL-1β. Adiponectin levels negatively correlated with TNFα and positively correlated with IL-1β. IL-1β positively correlated with IL-6 and negatively correlated with TNFα and IL-17. Conclusion Circulating Leptin, Resistin, IL-6 and IL-17 levels positively correlate with RA clinical activity in a manner independent of the subject's BMI. Complex relationships between inflammatory cytokines were observed in RA patients suggesting that other metabolic or inflammatory factors could be involved. |
| Databáze: | OpenAIRE |
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