Obesity and childhood asthma in male schoolchildren in Saudi Arabia: Is there a role for leptin, interleukin-4, interleukin-5, and interleukin-21?
| Autor: | Aamir Magzoub, Wed Ahmad Alaseeri, Iman Nasser, Ahmed Morad Asaad, Saeed Ali Alsareli, Alzahrani Mohammed Jamaan, Khalid Alshaybari, Dhafer Alshehri, Mohammed Helmy Faris Shalayel, Ahmed A. Mahfouz, Mohamed Ansar Qureshi, Mohammed Saeed Zayed Al-Ayed, Hamdan Saad Alaamri |
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| Rok vydání: | 2019 |
| Předmět: |
Leptin
Male Pediatric Obesity Chemokine Adolescent Saudi Arabia lcsh:Medicine Adipokine 030209 endocrinology & metabolism 03 medical and health sciences Interleukin 21 0302 clinical medicine medicine Humans 030212 general & internal medicine Child Interleukin 5 Interleukin 4 Asthma biology business.industry Interleukins lcsh:R General Medicine medicine.disease Obesity Cross-Sectional Studies Immunology biology.protein Original Article Interleukin-4 Interleukin-5 business |
| Zdroj: | Annals of Saudi Medicine, Vol 39, Iss 5, Pp 295-301 (2019) Annals of Saudi Medicine |
| ISSN: | 0975-4466 0256-4947 |
| Popis: | BACKGROUND: Adiposity is associated with high serum levels of adipokines and chemokines which are possibly implicated in a co-existence of obesity and asthma. OBJECTIVES: Elucidate the possible roles of leptin, interleukin (IL)-4, IL-5 and IL-21 in linking obesity with childhood asthma. DESIGN: Cross-sectional, analytical. SETTING: Population of schoolchildren in a small Saudi city. SUBJECTS AND METHODS: The study included a representative sample of Saudi schoolchildren grouped as obese asthmatics, non-obese asthmatics, or obese nonasthmatics, with nonobese nonasthmatics as a control group. An asthma control test was done for the asthmatic groups. MAIN OUTCOME MEASURES: Serum levels of leptin, IL-4, IL-5, and IL-21. SAMPLE SIZE: 345 male schoolchildren with a mean (SD) age of 13.0 (2.3) years. RESULTS: Median serum leptin concentrations in obese asthmatics were significantly higher than in nonobese asthmatics (P |
| Databáze: | OpenAIRE |
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