Anthelmintic Efficacy of Amoscanate (C 9333-Go/CGP 4540) Against Various Infections in Rodents, Dogs and Monkeys
| Autor: | Himansu G. Sen, Birendra N. Deb |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Veterinary medicine Helminthiasis Administration Oral Biology Necator americanus Necatoriasis Single oral dose Mice chemistry.chemical_compound Dogs Isothiocyanates Cricetinae Virology parasitic diseases medicine Animals Anthelmintic Parasite Egg Count Feces Anthelmintics Oesophagostomum Aniline Compounds Mesocricetus Amoscanate Diphenylamine biology.organism_classification Macaca mulatta Infectious Diseases chemistry Nematospiroides dubius Parasitology Ancylostoma caninum Thiocyanates medicine.drug |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 30:992-998 |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | The anthelmintic activity of Amoscanate (C 9333-GO/CGP 4540) has been studied in experimental infections with the human hookworm, Necator americanus, in hamsters; Nematospiroides dubius, Hymenolepsis nana and natural infections with Syphacia obvelata in mice; Ancylostoma caninum, A. ceylanicum in mongrel dogs; Oesophagostomum apiostumum and Strongyloides fuelleborni in rhesus monkeys. Single oral doses of 30–60 mg/kg eliminated 94 to 99% of the total Necator parasites in 37-day-old non-patent infection, while single oral doses of 25 mg/kg expelled the entire worm burden in patent infection in hamsters. When incorporated in feed at the 0.01% level and administered ad lib. to hamsters at 20, 27 and 34 days postexposure for 5 days, the worm burdens were reduced 88 to 94%. N. dubius was completely eradicated by a single oral dose of 200 mg/kg while S. obvelata and N. nana were expelled at doses of 12.6 mg/kg and 50 mg/kg, respectively. A dose of 25 mg/kg in dogs produced 100% fecal egg reduction in hookworm and 99% in ascarid infections. The drug at 3 × 2.5 mg/kg administered at 4-hour intervals produced similar effects in mixed A. caninum and A. ceylanicum infections. Against natural infections of S. fulleborni and Oe. apiostumum in rhesus monkeys the drug showed 100% efficacy at a dosage of 60 mg/kg administered thrice at 12-hour intervals. |
| Databáze: | OpenAIRE |
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